37460-89-2Relevant academic research and scientific papers
Novel and versatile methodology for synthesis of cyclic imides and evaluation of their cytotoxic, DNA binding, apoptotic inducing activities and molecular modeling study
Abdel-Aziz, Alaa A.-M.
, p. 614 - 626 (2007)
Versatile method has been developed for synthesis of N-substituted imides. Thus, acid anhydrides, imides and dicarboxylic acids were successfully subjected to dehydrative cyclization with substituted amines using DPPOx and Et3N to afford N-substituted imides under mild conditions. The DNA binding and apoptosis induction were investigated with regard to their potential utility as cytotoxic agents. Molecular modeling methods are used to study the cytotoxic activity of the active compounds by means of molecular and quantum mechanics.
Preparing method for N-substituted pyrrolo [3,4-B] pyrazine-5,7(6H)-diketone
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Paragraph 0023, (2017/08/23)
The invention relates to a preparing method for a dexzopiclone intermediate N-substituted pyrrolo [3,4-B] pyrazine-5,7(6H)-diketone, in particular to preparation of 6-(5-chloropyridine-2-yl)-5H-pyrrolo [3,4-B] pyrazine-5,7(6H)-diketone. According to the preparation method, N-substituted pyrrolo [3,4-B] pyrazine-5,7(6H)-diketone is prepared with triphosgene/triphenylphosphine oxide serving as a reaction reagent, as the product is a crystalline solid and is slightly soluble in an organic solvent while a catalyst is soluble in the organic solvent, the product can be obtained through direct suction filtration, and posttreatment is convenient; besides, a mother solution can be directly and consecutively reused, cyclic use of aryl oxide phosphate and the solvent is achieved, and the preparing method has the advantages that operation is simple, the reaction conditions are mild, the yield is high, and the quantity of three wastes is small; use of highly-corrosive toxic reagents such as thionyl chloride and chloroformate is avoided from the source, and high implementation value and social and economic benefits are achieved.
