37460-91-6Relevant academic research and scientific papers
Preparing method for N-substituted pyrrolo [3,4-B] pyrazine-5,7(6H)-diketone
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Paragraph 0025, (2017/08/23)
The invention relates to a preparing method for a dexzopiclone intermediate N-substituted pyrrolo [3,4-B] pyrazine-5,7(6H)-diketone, in particular to preparation of 6-(5-chloropyridine-2-yl)-5H-pyrrolo [3,4-B] pyrazine-5,7(6H)-diketone. According to the preparation method, N-substituted pyrrolo [3,4-B] pyrazine-5,7(6H)-diketone is prepared with triphosgene/triphenylphosphine oxide serving as a reaction reagent, as the product is a crystalline solid and is slightly soluble in an organic solvent while a catalyst is soluble in the organic solvent, the product can be obtained through direct suction filtration, and posttreatment is convenient; besides, a mother solution can be directly and consecutively reused, cyclic use of aryl oxide phosphate and the solvent is achieved, and the preparing method has the advantages that operation is simple, the reaction conditions are mild, the yield is high, and the quantity of three wastes is small; use of highly-corrosive toxic reagents such as thionyl chloride and chloroformate is avoided from the source, and high implementation value and social and economic benefits are achieved.
Synthesis, molecular modeling study, preliminary antibacterial, and antitumor evaluation of N-substituted naphthalimides and their structural analogues
El-Azab, Adel S.,Alanazi, Amer M.,Abdel-Aziz, Naglaa I.,Al-Suwaidan, Ibrahim A.,El-Sayed, Magda A. A.,El-Sherbeny, Magda A.,Abdel-Aziz, Alaa A.-M.
, p. 2360 - 2375 (2013/07/26)
Carboxylic acid imides 1-26 have been synthesized and screened for their antibacterial against gram-positive and gram-negative organisms and their antitumor activity against 60 tumor cell lines taken from nine different organs. Compounds 12, 14, and 16 we
