37461-62-4

Usage

Type of compound

Heterocyclic organic compound

Structure

Five-membered ring with three carbon atoms, one nitrogen atom, one sulfur atom, and one fluorine atom

Usage

Building block in the synthesis of pharmaceuticals and agrochemicals

Biological and pharmacological activities

Potential activities due to its structure

Application

Precursor in the development of materials for electronic and optoelectronic applications

Unique property

Presence of trifluoromethyl group

Importance

Valuable component in the design and synthesis of new chemical entities and materials

Upstream product

• 37461-61-3 2-bromo-5-(trifluoromethyl)-1,3,4-thiadiazole 
• 17356-08-0 thiourea 

Downstream Products

• 62617-03-2 2-(2-chloro-benzylsulfanyl)-5-trifluoromethyl-[1,3,4]thiadiazole 

Relevant academic research and scientific papers

CARBACEPHEM β-LACTAM ANTIBIOTICS

Carbacephem -lactam antibiotics having structure (I) are disclosed, including stereoisomers, pharmaceutically acceptable salts, esters and prodrugs thereof, wherein Ar1, Ar2, R1 and R2 are as defined herein. The compounds are useful for the treatment of bacterial infections, in particular those caused by methicillin-resistant Staphylococcus spp.

CARBACEPHEM BETA-LACTAM ANTIBIOTICS

Carbacephem β-lactam antibiotics having chemical structures (I) and (II) are disclosed: including stereoisomers, pharmaceutically acceptable salts, esters and prodrugs thereof, wherein Ar2, R1, R2 and R6 are as defined herein. The compounds are useful for the treatment of bacterial infections, in particular those caused by methicillin-resistant Staphylococcus spp.

2-Substituted-5-trifluoromethyl-1,3,4-thiadiazoles

2-Substituted-5-trifluoromethyl-1,3,4-thiadiazoles of the formula STR1 in which R is substituted alkyl, phenyl monosubstituted in the o- or m- position, polysubstituted phenyl, substituted phenylalkyl, phenylalkenyl, substituted phenylalkenyl, an optionally substituted 5-membered or 6-membered heterocyclic radical with 1 to 4 hetero-atoms selected from N and S atoms, optionally substituted benzimidazolyl or benzthiazolyl, optionally substituted naphthyl, quinolyl, cyano or one of the groups STR2 wherein R1 and R2 conjointly are a trimethylene, tetramethylene or pentamethylene group, X is oxygen or sulfur, R' and R" each independently is alkyl or, together with the nitrogen atom and optionally further hetero-atoms selected from O and N atoms, form an optionally substituted 6-membered or 7-membered ring, and N is 0, 1 or 2, Which possess fungicidal, bactericidal, arthropodicidal and insecticidal properties.