374633-36-0

Usage

InChI:InChI=1/C6H5BrFN/c1-4-2-3-5(8)6(7)9-4/h2-3H,1H3

Upstream product

• 126325-53-9 3-amino-2-bromo-6-methylpyridine 

Downstream Products

• 1046788-35-5 tert-butyl 3-[(3-fluoro-6-methylpyridin-2-yl)amino]-6,6-dimethyl-1-{[2-(trimethylsilyl)ethoxy]methyl}-4,6-dihydropyrrolo[3,4-c]pyrazole-5(1H)-carboxylate 
• 1210419-19-4 6-(2,6-difluorophenyl)-5-fluoropyridine-2-carboxylic acid 
• 1210419-26-3 methyl 6-bromo-5-fluoropyridine-2-carboxylate 
• 1210419-29-6 methyl 6-(2,6-difluoro-4-methoxyphenyl)-5-fluoropicolinate 
• 1210419-31-0 6-(2,6-difluoro-4-methoxyphenyl)-5-fluoropicolinic acid 
• 1355011-15-2 6-(2,6-difluoro-3-nitrophenyl)-5-fluoropicolinic acid 
• 1355011-17-4 methyl 6-(3-amino-2,6-difluorophenyl)-5-fluoropicolinate 
• 1355011-16-3 methyl 6-(2,6-difluoro-3-nitrophenyl)-5-fluoropicolinate 
• 1355011-18-5 methyl 6-(3-acetamido-2,6-difluorophenyl)-5-fluoropicolinate 
• 1395986-06-7 methyl 6-(3-(((S)-2,2-dimethyl-1,3-dioxolan-4-yl)methoxy)-2,6-difluorophenyl)-5-fluoropicolinate 
• 1395986-13-6 6-(3-(((S)-2,2-dimethyl-1,3-dioxolan-4-yl)methoxy)-2,6-difluorophenyl)-5-fluoropicolinic acid 
• 1401163-73-2 3-fluoro-6-methyl-6'-(trifluoromethyl)-2,3'-bipyridine 
• 1469924-93-3 tert-butyl (3R,4R,5S)-4-(tert-butyldimethylsilyloxy)-1-(3-(6-(2,6-difluorophenyl)-5-fluoropicolinamido)pyridin-4-yl)-5-methylpiperidin-3-ylcarbamate 
• 1210417-75-6 N-(4-((3R,4R,5S)-3-amino-4-hydroxy-5-methylpiperidin-1-yl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide 

Relevant academic research and scientific papers

Synthesis and biological evaluation of 5-(fluoro-substituted-6-methylpyridin-2-yl)-4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)imidazoles as inhibitors of transforming growth factor-β type i receptor kinase

To further optimize a clinical candidate 5 (EW-7197), a series of 5-(3-, 4-, or 5-fluoro-substituted-6-methylpyridin-2-yl)-4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)imidazoles 19a-l have been synthesized and evaluated for their TGF-β type I receptor kinase (ALK5) and p38α MAP kinase inhibitory activity in an enzyme assay. The 5-(5-fluoro-substituted-6-methylpyridin-2-yl)-4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)imidazoles 19h-l displayed the similar level of potency to that of 5 against both ALK5 (IC50 = 7.68-13.70 nM) and p38α MAP kinase (IC50 = 1240-3370 nM). Among them, 19j inhibited ALK5 with IC50 value of 7.68 nM in a kinase assay and displayed 82% inhibition at 100 nM in a luciferase reporter assay.