37478-58-3

Usage

Uses

Used in Pharmaceutical Industry:
2-(PIPERAZIN-1-YL)-ACETIC ACID H2O is used as a precursor in the production of antihistamines and antipsychotic drugs, contributing to the development of medications that address a range of health conditions. Its role in the synthesis of these drugs is crucial for their therapeutic effects.
Used in Organic Chemistry:
In the realm of organic chemistry, 2-(PIPERAZIN-1-YL)-ACETIC ACID H2O is utilized in the synthesis of polymers, playing a significant role in the creation of materials with specific properties tailored for various applications.
Used as a Chelating Agent in Metal Complexation:
2-(PIPERAZIN-1-YL)-ACETIC ACID H2O also serves as a chelating agent, enabling the complexation of metals. This function is vital for applications where metal binding and stabilization are required, such as in catalysis or the development of new materials with unique properties.
Used in Materials Science:
2-(PIPERAZIN-1-YL)-ACETIC ACID H2O has potential applications in materials science, where its ability to form complexes and interact with other molecules can lead to the discovery and engineering of novel materials with specific characteristics for use in various industries.

Upstream product

• 110-85-0 piperazine 
• 79-08-3 bromoacetic acid 
• 79-11-8 chloroacetic acid 
• 180576-04-9 tert-butyl 4-(2-(tert-butoxy)-2-oxoethyl)piperazine-1-carboxylate 
• 120-43-4 4-ethoxycarbonylpiperazine 

Downstream Products

• 1153874-83-9 C₁₄H₁₉N₃O₃ 
• 1154634-90-8 C₁₅H₂₁N₃O₃ 
• 1155160-03-4 C₁₄H₁₈ClN₃O₃ 
• 1226513-51-4 C₁₅H₂₁N₃O₄ 
• 1434558-88-9 O²-(2,4-dinitro-5-(4-(carboxymethyl)piperazin-1-yl)) 1-(N-methylethanolamino)diazen-1-ium-1,2-diolate 

Relevant academic research and scientific papers

Effect of H4R antagonist N-(2-aminoethyl)-5-chloro-1H-indol-2-carboxamides and 5-chloro-2-(piperazin-1-ylmethyl)-1H-benzimidazole on histamine and 4-methylhistamine-induced mast cell response

Context: The histamine plays a decisive role in acute and chronic inflammatory responses and is regulated through its four types of distinct receptors designated from H1 to H4. Recently histamine 4 receptor (H4R) antagonists have been reported to possess various pharmacological effects against various allergic diseases. Objective: To investigate the inhibitory effect of N-(2-aminoethyl)-5-chloro-1H-indol-2-carboxamide (Compound A) and 5-chloro-2-(piperazin-1-ylmethyl)-1H-benzimidazole (Compound L) on H4R-mediated calcium mobilization, cytokine IL-13 production, ERK1/2, Akt and NF-κB activation in human mastocytoma cells-1 (HMC-1). Materials and methods: Compounds A and L were synthesized chemically and their inhibitory effect on intracellular calcium release was analyzed by Fluo-4 calcium assay, cytokine measurement through ELISA and activation of signaling molecules by western blot. Results: Pre-treatment with compounds A and L significantly reduced the H4R-mediated intracellular calcium release. Histamine and 4-methylhistamine (4-MH) induced Th2 cytokine IL-13 production in HMC-1 cells, was inhibited by compound A (77.61%, 74.25% at 1 μM concentration) and compound L (79.63%, 81.70% at 1 μM concentration). Furthermore, histamine induced the phosphorylation of ERK1/2, Akt and NF-κB was suppressed by compounds A and L at varying levels, ERK1/2 (88%, 86%), Akt (88%, 89%) and NF-κB (89%, 87%) in HMC-1 cells. Discussion and conclusions: Taken together these data demonstrate that compound A and compound L may block H4R-mediated downstream signaling events.

NOVEL TETRAHYDROPYRIDOPYRIMIDINES FOR THE TREATMENT AND PROPHYLAXIS OF HBV INFECTION

The present invention provides novel compounds having general formula (I), wherein R1 to R4, A, W, Q and Y are as described herein, compositions including the compounds and methods of using the compounds.

NOVEL MULTIMERIC MOLECULES, A PROCESS FOR PREPARING THE SAME AND THE USE THEREOF FOR MANUFACTURING MEDICINAL DRUGS

The invention relates to a compound of the formula (I): in which k and j are independently 0 or 1, Y is a macrocycle in which the cycle includes 9 to 36 carbon atoms and is functionalised by three amino functions and by a chain for attaching the spacer arm Z via an X bond, Rc is a binding pattern with a receptor of the TNF superfamily, X is a chemical function for binding the Y group to the space arm, and Z is a bi-, tri- or tetra-functional spacer arm.

NOVEL MULTIMERIC CD40 LIGANDS, METHOD FOR PREPARING SAME AND USE THEREOF FOR PREPARING DRUGS

The invention concerns a compound of formula (I), wherein Y represents a macrocycle whereof the cycle comprises 9 to 36 atoms, and is functionalized by three amine or COOH functions; Rc represents a group of formula H—Xa—Xb—Xc—Xd—Xe—(Xf)i—, wherein i represents 0 or 1, Xn is in particular selected among lysine, arginine, ornithine residues, Xb is in particular selected among glycine, asparagine, L-proline or D-proline residues, Xc et Xd are in particular selected among tyrosine, phenylalanine or 3-nitrotyrosine residues, Xe et Xf are in particular selected among the following amino acid residues: NH2—(CH2)n—COOH, n ranging from 1 to 10 or NH2—(CH2—CH2—O)m—CH2CH2COOH, m ranging from 3 to 6, provided that one at least of the amino acid residues Xa, Xb, Xc and Xd is different from the corresponding amino acid in the sequence of the natural CD40 143Lys-Gly-Tyr-Tyr146 fragment

Compositions and kits pertaining to analyte determination

This invention pertains to methods, mixtures, kits and/or compositions for the determination of analytes by mass analysis using unique labeling reagents or sets of unique labeling reagents. The labeling reagents can be isomeric or isobaric and can be used to produce mixtures suitable for multiplex analysis of the labeled analytes.