37478-58-3

Basic information

• Product Name: 2-(PIPERAZIN-1-YL)-ACETIC ACID H2O
• Synonyms: 2-(PIPERAZIN-1-YL)ACETIC ACID;2-(PIPERAZIN-1-YL)-ACETIC ACID H2O;2-(PIPERAZIN-1-YL)ACETIC ACID HYDRATE;AKOS BB-5495;IFLAB-BB F1929-1681;PIPERAZIN-1-YL-ACETIC ACID;TIMTEC-BB SBB010118;1-PIPERAZINYLACETIC ACID
• CAS NO: 37478-58-3
• Molecular Formula: C₆H₁₂N₂O₂
• Molecular Weight: 162.19
• Product Categories: pharmacetical
• Mol File: 37478-58-3.mol
• Article Data: 5

Chemical Properties

• Melting Point: >220°C
• Boiling Point: 292.6 °C at 760mmHg
• Flash Point: 130.7 °C
• Appearance: /
• Density: 1.146 g/cm³
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 1.85±0.10(Predicted)
• CAS DataBase Reference: 2-(PIPERAZIN-1-YL)-ACETIC ACID H2O(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(PIPERAZIN-1-YL)-ACETIC ACID H2O(37478-58-3)
• EPA Substance Registry System: 2-(PIPERAZIN-1-YL)-ACETIC ACID H2O(37478-58-3)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 37478-58-3(Hazardous Substances Data)

Usage

General Description

2-(Piperazin-1-yl)-acetic acid, also known as piperazine acetic acid, is a chemical compound composed of a piperazine ring and an acetic acid group. It is often found in the form of a hydrate with one molecule of water attached. 2-(PIPERAZIN-1-YL)-ACETIC ACID H2O is commonly used as a building block in the synthesis of various pharmaceuticals and other organic compounds. Piperazine acetic acid has a wide range of applications, including as a precursor for the production of antihistamines, antipsychotic drugs, and other medications. It is also used in the synthesis of polymers and as a chelating agent in metal complexation. Additionally, this compound has potential applications in the field of materials science and organic chemistry.

Upstream product

• 120-43-4 4-ethoxycarbonylpiperazine 
• 79-08-3 bromoacetic acid 
• 110-85-0 piperazine 
• 79-11-8 chloroacetic acid 
• 180576-04-9 tert-butyl 4-(2-(tert-butoxy)-2-oxoethyl)piperazine-1-carboxylate 

Downstream Products

• 1153874-83-9 C₁₄H₁₉N₃O₃ 
• 1154634-90-8 C₁₅H₂₁N₃O₃ 
• 1155160-03-4 C₁₄H₁₈ClN₃O₃ 
• 1226513-51-4 C₁₅H₂₁N₃O₄ 
• 1434558-88-9 O²-(2,4-dinitro-5-(4-(carboxymethyl)piperazin-1-yl)) 1-(N-methylethanolamino)diazen-1-ium-1,2-diolate 

Relevant articles and documents

Effect of H4R antagonist N-(2-aminoethyl)-5-chloro-1H-indol-2-carboxamides and 5-chloro-2-(piperazin-1-ylmethyl)-1H-benzimidazole on histamine and 4-methylhistamine-induced mast cell response

Context: The histamine plays a decisive role in acute and chronic inflammatory responses and is regulated through its four types of distinct receptors designated from H1 to H4. Recently histamine 4 receptor (H4R) antagonists have been reported to possess various pharmacological effects against various allergic diseases. Objective: To investigate the inhibitory effect of N-(2-aminoethyl)-5-chloro-1H-indol-2-carboxamide (Compound A) and 5-chloro-2-(piperazin-1-ylmethyl)-1H-benzimidazole (Compound L) on H4R-mediated calcium mobilization, cytokine IL-13 production, ERK1/2, Akt and NF-κB activation in human mastocytoma cells-1 (HMC-1). Materials and methods: Compounds A and L were synthesized chemically and their inhibitory effect on intracellular calcium release was analyzed by Fluo-4 calcium assay, cytokine measurement through ELISA and activation of signaling molecules by western blot. Results: Pre-treatment with compounds A and L significantly reduced the H4R-mediated intracellular calcium release. Histamine and 4-methylhistamine (4-MH) induced Th2 cytokine IL-13 production in HMC-1 cells, was inhibited by compound A (77.61%, 74.25% at 1 μM concentration) and compound L (79.63%, 81.70% at 1 μM concentration). Furthermore, histamine induced the phosphorylation of ERK1/2, Akt and NF-κB was suppressed by compounds A and L at varying levels, ERK1/2 (88%, 86%), Akt (88%, 89%) and NF-κB (89%, 87%) in HMC-1 cells. Discussion and conclusions: Taken together these data demonstrate that compound A and compound L may block H4R-mediated downstream signaling events.

NOVEL MULTIMERIC MOLECULES, A PROCESS FOR PREPARING THE SAME AND THE USE THEREOF FOR MANUFACTURING MEDICINAL DRUGS

The invention relates to a compound of the formula (I): in which k and j are independently 0 or 1, Y is a macrocycle in which the cycle includes 9 to 36 carbon atoms and is functionalised by three amino functions and by a chain for attaching the spacer arm Z via an X bond, Rc is a binding pattern with a receptor of the TNF superfamily, X is a chemical function for binding the Y group to the space arm, and Z is a bi-, tri- or tetra-functional spacer arm.

Compositions and kits pertaining to analyte determination

This invention pertains to methods, mixtures, kits and/or compositions for the determination of analytes by mass analysis using unique labeling reagents or sets of unique labeling reagents. The labeling reagents can be isomeric or isobaric and can be used to produce mixtures suitable for multiplex analysis of the labeled analytes.