374782-52-2

Basic information

• Product Name: methyl 3-O-benzyl-2-deoxy-2-fluoro-β-D-arabinofuranoside
• Synonyms: methyl 3-O-benzyl-2-deoxy-2-fluoro-β-D-arabinofuranoside
• CAS NO: 374782-52-2
• Molecular Weight: 256.274
• Mol File: 374782-52-2.mol

Chemical Properties

• CAS DataBase Reference: methyl 3-O-benzyl-2-deoxy-2-fluoro-β-D-arabinofuranoside(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 3-O-benzyl-2-deoxy-2-fluoro-β-D-arabinofuranoside(374782-52-2)
• EPA Substance Registry System: methyl 3-O-benzyl-2-deoxy-2-fluoro-β-D-arabinofuranoside(374782-52-2)

Safety Data

• Hazardous Substances Data: 374782-52-2(Hazardous Substances Data)

Upstream product

• 379216-00-9 C₂₀H₁₉FO₆ 
• 136315-44-1 2-Deoxy-2-fluoro-1-O-methyl-β-D-arabinofuranose 
• 97614-44-3 2-deoxy-2-fluoro-3,5-di-O-benzoyl-α-D-arabinofuranosyl bromide 
• 374782-51-1 methyl 3,5-di-O-benzyl-2-deoxy-2-fluoro-β-D-arabinofuranoside 

Downstream Products

• 379216-02-1 2,6-dichloro-9-(3,5,6-tri-O-benzoyl-2-deoxy-2-fluoro-4-C-hydroxymethyl-D-arabinofuranosyl)-9H-purine 
• 374782-59-9 methyl 3,5,6-tri-O-benzoyl-2-deoxy-2-fluoro-4-C-hydroxymethyl-β-D-arabinofuranoside 
• 379216-01-0 methyl 3-O-benzyl-2-deoxy-2-fluoro-4-C-hydroxymethyl-β-D-arabinofuranoside 
• 374782-53-3 (2S,3R,4S,5R)-3-Benzyloxy-4-fluoro-5-methoxy-tetrahydro-furan-2-carbaldehyde 

Relevant articles and documents

Synthesis and biological activity of 4′-C-hydroxymethyl-2′ fluoro-D-arabinofuranosylpurine nucleosides

A series of 4′-C-hydroxymethyl-2′-fluoro-D-arabinofuranosylpurine nucleosides was prepared and evaluated for cytotoxicity in human tumor cell lines. A convenient synthesis of the carbohydrate precursor 4-C-hydroxymethyl-3,5-di-O-benzoyl-2-fluoro-α-D-arabi

Synthesis and biological activity of 4′-C-hydroxymethyl-2′-fluoro-D-arabinofuranosylpurine nucleosides

A series of 4′-C-hydroxymethyl-2′-fluoro-D-arabinofuranosylpurine nucleosides was prepared and evaluated for cytotoxicity. The details of a convenient synthesis of the carbohydrate precursor 4-C-hydroxymethyl-3,5-di-O-benzoyl-2-fluoro-α-D-arabinofuranosyl bromide (13) are presented. Proof of the structure and configuration at all chiral centers of the sugars and the nucleosides were obtained by proton NMR. All five target nucleosides were evaluated for cytotoxicity in human tumor cell lines. The 4′-C-hydroxymethyl clofarabine analogue (16β) showed slight cytotoxicity in CCRF-CEM leukemia cells.