374783-78-5 Usage
General Description
(S)-2-Methyl-1-(4-nitrobenzenesulfonyl)aziridine is a chemical compound with a molecular formula of C9H10N2O5S. It is a sulfonamide aziridine compound that has a bright yellow color and is soluble in organic solvents. (S)-2-METHYL-1-(4-NITROBENZENESULFONYL)AZIRIDINE is often used as a building block in organic synthesis, particularly in the production of pharmaceuticals and agrochemicals. It can also be used as a reagent in the synthesis of various aziridine derivatives. Additionally, it has been studied for its potential anti-cancer properties and for its ability to inhibit the growth of certain cancer cell lines. However, it is important to handle this chemical with care, as it is toxic and may cause skin and eye irritation.
Check Digit Verification of cas no
The CAS Registry Mumber 374783-78-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,7,4,7,8 and 3 respectively; the second part has 2 digits, 7 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 374783-78:
(8*3)+(7*7)+(6*4)+(5*7)+(4*8)+(3*3)+(2*7)+(1*8)=195
195 % 10 = 5
So 374783-78-5 is a valid CAS Registry Number.
InChI:InChI=1/C9H10N2O4S/c1-7-6-10(7)16(14,15)9-4-2-8(3-5-9)11(12)13/h2-5,7H,6H2,1H3/t7-,10?/m0/s1
374783-78-5Relevant articles and documents
Microwave-assisted ring-opening of activated aziridines with resin-bound amines
Crestey, Francois,Witt, Matthias,Frydenvang, Karla,Staerk, Dan,Jaroszewski, Jerzy W.,Franzyk, Henrik
, p. 3566 - 3569 (2008/09/20)
(Chemical Equation Presented) This paper describes the first study of nucleophilic ring-opening of nosylamide-activated aziridines under microwave irradiation conditions in solid-phase synthesis (SPS). The effects of solvent, temperature, reaction time, a
β3-Amino acids by nucleophilic ring-opening of N-nosyl aziridines
Farràs, Jaume,Ginesta, Xavier,Sutton, Peter W,Taltavull, Joan,Egeler, Frank,Romea, Pedro,Urpí, Fèlix,Vilarrasa, Jaume
, p. 7665 - 7674 (2007/10/03)
N-Nosyl aziridines can be easily prepared from 1,2-amino alcohols derived from α-amino acids. Nucleophilic ring-opening of N-nosyl aziridines with cyanide ions followed by hydrolysis of the corresponding nitriles lead to N-nosyl β3-amino acids, which can be readily converted into a variety of derivatives bearing adequate functionality for peptide synthesis. The proposed methodology is simple, efficient, and amenable to large-scale preparations.