37481-18-8

Basic information

• Product Name: 2-(3,4-DIHYDRO-2H-QUINOLIN-1-YL)-ETHYLAMINE
• Synonyms: CHEMBRDG-BB 4003435;2-(3,4-DIHYDRO-2H-QUINOLIN-1-YL)-ETHYLAMINE;N-(2-Aminoethyl)-1,2,3,4-tetrahydroquinoline;2-(3,4-Dihydroquinolin-1(2H)-yl)ethanamine;1(2H)-Quinolineethanamine, 3,4-dihydro-;2-(3,4-dihydroquinolin-1(2H)-yl)ethanamine(SALTDATA: 2HCl 0.2H2O)
• CAS NO: 37481-18-8
• Molecular Formula: C11H16N2
• Molecular Weight: 176.26
• Mol File: 37481-18-8.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 318.8 °C at 760 mmHg
• Flash Point: 128.4 °C
• Appearance: /
• Density: 1.045 g/cm³
• Refractive Index: 1.564
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 8.80±0.10(Predicted)
• CAS DataBase Reference: 2-(3,4-DIHYDRO-2H-QUINOLIN-1-YL)-ETHYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3,4-DIHYDRO-2H-QUINOLIN-1-YL)-ETHYLAMINE(37481-18-8)
• EPA Substance Registry System: 2-(3,4-DIHYDRO-2H-QUINOLIN-1-YL)-ETHYLAMINE(37481-18-8)

Safety Data

• Hazardous Substances Data: 37481-18-8(Hazardous Substances Data)

Usage

General Description

2-(3,4-Dihydro-2H-quinolin-1-yl)-ethylamine is a chemical compound with the formula C13H18N2. It is a derivative of 2H-quinoline, which is a heterocyclic aromatic compound. This chemical has a unique structure with a quinoline ring and an ethylamine group. It can be used in the synthesis of various pharmaceuticals and organic compounds due to its heterocyclic nature and amine functionality. Additionally, it may exhibit biological activity due to its structural features, making it of interest in the field of medicinal chemistry and drug development.

InChI:InChI=1/C11H16N2/c12-7-9-13-8-3-5-10-4-1-2-6-11(10)13/h1-2,4,6H,3,5,7-9,12H2

Upstream product

• 91-22-5 quinoline 
• 635-46-1 1,2,3,4-tetrahydroisoquinoline 
• 2576-47-8 2-bromoethylamine hydrobromide 
• 66487-31-8 2-(3,4-dihydroquinolin-1(2H)-yl)acetonitrile 
• 689-98-5 chloroethylamine 

Downstream Products

• 1201219-12-6 perfluorophenyl 4-(4-(4-(5-(2-(3,4-dihydroquinolin-1(2H)-yl)ethylcarbamoyl)-1-methyl-1H-pyrrol-3-ylcarbamoyl)benzoyl)benzamido)-1-methyl-1H-pyrrole-2-carboxylate 

Relevant articles and documents

Discovery of a lead series of potent benzodiazepine 5-HT2C receptor agonists with high selectivity in functional and binding assays

A series of potential new 5-HT2 receptor scaffolds based on a simplification of the clinically studied, 5-HT2CR agonist vabicaserin, were designed. An in vivo feeding assay early in our screening process played an instrumental part in the lead identification process, leading us to focus on a 6,5,7-tricyclic scaffold. A subsequent early SAR investigation provided potent agonists of the 5-HT2C receptor that were highly selective in both functional and binding assays, had good rat PK properties and that significantly reduced acute food intake in the rat.

Electrooxidative cyclization of hydroquinolyl alcohols, hydroquinolylamines, and dimethyl aminomalonates

Several hydroquinolyl alcohols and amines were electrochemically oxidized in methanol in the presence of sodium methoxide and potassium iodide to afford the corresponding intramolecular cyclization products. Furthermore, several amino malonates were electrochemically oxidized to yield the corresponding heterocyclic compounds through an intramolecular carbon-carbon bond formation in the presence of sodium cyanide in methanol. CSIRO 2007.