37481-18-8

Usage

Uses

Used in Pharmaceutical Synthesis:
2-(3,4-Dihydro-2H-quinolin-1-yl)-ethylamine is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the formation of complex molecular structures with potential therapeutic properties.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, 2-(3,4-Dihydro-2H-quinolin-1-yl)-ethylamine is utilized as a structural component in the design and development of new drugs, leveraging its heterocyclic and amine functionalities to explore novel biological activities and mechanisms of action.
Used in Organic Compounds Synthesis:
2-(3,4-DIHYDRO-2H-QUINOLIN-1-YL)-ETHYLAMINE is also used as a building block in the synthesis of organic compounds, where its unique structure can impart specific chemical and physical properties to the final products, potentially useful in various chemical and material applications.

InChI:InChI=1/C11H16N2/c12-7-9-13-8-3-5-10-4-1-2-6-11(10)13/h1-2,4,6H,3,5,7-9,12H2

Upstream product

• 635-46-1 1,2,3,4-tetrahydroisoquinoline 
• 689-98-5 chloroethylamine 
• 2576-47-8 2-bromoethylamine hydrobromide 
• 91-22-5 quinoline 
• 66487-31-8 2-(3,4-dihydroquinolin-1(2H)-yl)acetonitrile 

Downstream Products

• 1201219-12-6 perfluorophenyl 4-(4-(4-(5-(2-(3,4-dihydroquinolin-1(2H)-yl)ethylcarbamoyl)-1-methyl-1H-pyrrol-3-ylcarbamoyl)benzoyl)benzamido)-1-methyl-1H-pyrrole-2-carboxylate 

Relevant academic research and scientific papers

Discovery of a lead series of potent benzodiazepine 5-HT2C receptor agonists with high selectivity in functional and binding assays

A series of potential new 5-HT2 receptor scaffolds based on a simplification of the clinically studied, 5-HT2CR agonist vabicaserin, were designed. An in vivo feeding assay early in our screening process played an instrumental part in the lead identification process, leading us to focus on a 6,5,7-tricyclic scaffold. A subsequent early SAR investigation provided potent agonists of the 5-HT2C receptor that were highly selective in both functional and binding assays, had good rat PK properties and that significantly reduced acute food intake in the rat.

Salts of 2- or 3-haloalkylamines in the synthesis of N-aminoalkyl derivatives of heterocyclic and aromatic amines

Reactions of 2-haloethyl- or 3-halopropylamine salts with NH-substrates (indoline, 1,2,3,4-tetrahydroquinoline, aniline, and N-ethylaniline) in the presence of NaHCO3 in water furnished various N-aminoalkyl derivatives of heterocyclic and aromatic amines.

Electrooxidative cyclization of hydroquinolyl alcohols, hydroquinolylamines, and dimethyl aminomalonates

Several hydroquinolyl alcohols and amines were electrochemically oxidized in methanol in the presence of sodium methoxide and potassium iodide to afford the corresponding intramolecular cyclization products. Furthermore, several amino malonates were electrochemically oxidized to yield the corresponding heterocyclic compounds through an intramolecular carbon-carbon bond formation in the presence of sodium cyanide in methanol. CSIRO 2007.

CARBOXAMIDE DERIVATIVE

An SGLT inhibitor comprising a compound of the formula: (|) wherein the ring A is an optionally substituted ring; R1 is an optionally substituted hydrocarbon group, etc.; each of R2 and R3 independently is a hydrogen atom, an optionally substituted hydrocarbon group, etc.; R4 is an optionally substituted hydrocarbon group, etc.; and X is a bivalent chain group whose main chain consists of 1 to 6 atoms. This SGLT inhibitor is useful as a preventive/therapeutic agent for diabetes mellitus, obesity, hypertension, hyperlipemia, etc.