37486-32-1Relevant academic research and scientific papers
Highly efficient alkylation to ketones and aldimines with Grignard reagents catalyzed by zinc(II) chloride
Hatano, Manabu,Suzuki, Shinji,Ishihara, Kazuaki
, p. 9998 - 9999 (2007/10/03)
A highly efficient alkylation to ketones and aldimines with Grignard reagents in the presence of catalytic trialkylzinc(II) ate complexes derived from ZnCl2 (10 mol %) in situ was developed. This simple Zn(II)-catalyzed alkylation could minimize the well-known but serious problems with the use of only Grignard reagents, which leads to reduction and aldol side products, and the yield of desired alkylation products could be improved. Copyright
