374887-19-1

Basic information

• Product Name: 2-[5-ethyl-4-(2-fluorophenyl)-4H-1,2,4-triazol-3-yl]-5-phenylpyridine
• Synonyms: 2-[5-ethyl-4-(2-fluorophenyl)-4H-1,2,4-triazol-3-yl]-5-phenylpyridine
• CAS NO: 374887-19-1
• Molecular Weight: 344.391
• Mol File: 374887-19-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-[5-ethyl-4-(2-fluorophenyl)-4H-1,2,4-triazol-3-yl]-5-phenylpyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[5-ethyl-4-(2-fluorophenyl)-4H-1,2,4-triazol-3-yl]-5-phenylpyridine(374887-19-1)
• EPA Substance Registry System: 2-[5-ethyl-4-(2-fluorophenyl)-4H-1,2,4-triazol-3-yl]-5-phenylpyridine(374887-19-1)

Safety Data

• Hazardous Substances Data: 374887-19-1(Hazardous Substances Data)

Upstream product

• 37531-72-9 N-(2-fluorophenyl)propionamide 
• 1446690-47-6 methyl N-(2-Fluorophenyl)propanimidothioate 
• 1446690-49-8 5-phenylpyridine-2-carbohydrazide 
• 75754-04-0 5-phenyl-pyridine-2-carboxylic acid 

Relevant articles and documents

Atropisomeric 4-phenyl-4 H -1,2,4-triazoles as selective glycine transporter 1 inhibitors

We report on the optimization of 4H-1,2,4-triazole derivatives to increase their activity and selectivity as glycine transporter 1 (GlyT1) inhibitors. Structure-activity relationship exploration resulted in the identification of a 3-[3-ethyl-5-(6-phenylpyridin-3-yl)-4H-1,2,4-triazol-4-yl]-2-methylbenzonitrile (14u) compound with markedly higher selectivity for GlyT1. Physiochemical studies revealed that 14u exists as a stable pair of atropisomers under physiological conditions. We successfully separated the atropisomers to obtain active enantiomer (R)-14u, which displayed favorable pharmacokinetic properties, as well as positive results in the mice Y-maze test.