37497-84-0

Basic information

• Product Name: METHYL 1-OXO-1,2-DIHYDRO-4-ISOQUINOLINECARBOXYLATE
• Synonyms: METHYL 1-OXO-1,2-DIHYDRO-4-ISOQUINOLINECARBOXYLATE;methyl 1,2-dihydro-1-oxoisoquinoline-4-carboxylate;1-Oxo-1,2-dihydro-isoquinoline-4-carboxylic acidmethylester;Methyl1-oxo-1,2-dihydroisoquinoline-4-carboxylate;1-Hydroxy-isoquinoline-4-carboxylic acid methyl ester
• CAS NO: 37497-84-0
• Molecular Formula: C₁₁H₉NO₃
• Molecular Weight: 203.19
• Mol File: 37497-84-0.mol
• Article Data: 4

Chemical Properties

• Melting Point: 259-261°C
• Boiling Point: 439.7°C at 760 mmHg
• Flash Point: 219.7°C
• Appearance: /
• Density: 1.288g/cm³
• Vapor Pressure: 6.25E-08mmHg at 25°C
• Refractive Index: 1.579
• Storage Temp.: 2-8°C
• CAS DataBase Reference: METHYL 1-OXO-1,2-DIHYDRO-4-ISOQUINOLINECARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 1-OXO-1,2-DIHYDRO-4-ISOQUINOLINECARBOXYLATE(37497-84-0)
• EPA Substance Registry System: METHYL 1-OXO-1,2-DIHYDRO-4-ISOQUINOLINECARBOXYLATE(37497-84-0)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 37497-84-0(Hazardous Substances Data)

Usage

General Description

Methyl 1-oxo-1,2-dihydro-4-isoquinolinecarboxylate is a chemical compound with the molecular formula C12H11NO3. It is a ester derivative of isoquinolinecarboxylic acid and is commonly used as a building block in the synthesis of various pharmaceutical compounds. It has been studied for its potential pharmacological properties, including its ability to act as a cholinesterase inhibitor and its potential use in the treatment of neurodegenerative diseases such as Alzheimer's. Additionally, it has been investigated for its potential role in the synthesis of novel bioactive molecules. Overall, methyl 1-oxo-1,2-dihydro-4-isoquinolinecarboxylate has shown promise in various research studies and holds potential for further exploration in pharmaceutical and medicinal chemistry.

InChI:InChI=1/C11H9NO3/c1-15-11(14)9-6-12-10(13)8-5-3-2-4-7(8)9/h2-6H,1H3,(H,12,13)

Upstream product

• 290-87-9 1,3,5-Triazine 
• 716-43-8 dimethyl homophthalate 
• 703-59-3 homophthalic anhydride 
• 186581-53-3 diazomethane 
• 34014-51-2 1,2-dihydro-1-oxo-4-isoquinolinecarboxylic acid 
• 78364-23-5 4-Methoxymethylen-3,4-dihydro-1H-2-benzopyran-1,3-dion 
• 78364-07-5 4-Aminomethylen-3,4-dihydro-1H-2-benzopyran-1,3-dion 
• 89-51-0 Homophthalic acid 

Downstream Products

• 1134629-93-8 C₁₈H₁₅NO₅S 
• 37497-86-2 1-chloro-isoquinoline-4-carboxylic acid methyl ester 

Relevant articles and documents

A new method using 1,3,5-triazine as an umpolung hydrogen cyanide equivalent toward the syntheses of isoquinolinone and 2-pyridone derivatives

An investigation of Hermecz and Hartenstein's cyclization methods was conducted. Overcoming the limited substrate scope allowed the expansion of the synthetic application of 1,3,5-triazine as an umpolung hydrogen cyanide equivalent. The reaction proceeded under mild conditions to provide various isoquinolinone and 2-pyridone derivatives with excellent yields.

Bicyclic and tricyclic heteroaromatic compounds

Disclosed are compounds of the formula: and the pharmaceutically acceptable salts thereof, wherein W, Q, X, X1, Y and Z are as defined herein. These compounds bind with high selectivity and/or high affinity to the benzodiazepine site of GABAsu