37505-07-0Relevant articles and documents
UTILISATION DES ALCOXYTRIALKYLALUMINATES EN SYNTHESE ASYMETRIQUE: SYNTHESE DE L'ACIDE HYDROXY-2, METHYL-2 BUTANOIQUE ENANTIOMERIQUEMENT ENRICHI EN R OU S
Vegh, D.,Boireau, G.,Henry-Basch, E.
, p. 127 - 132 (1984)
The reaction of LiAlEt3OR* with (-)-menthyl pyruvate (R*OH = (-)-N-methylephedrine) and with (+)-menthyl pyruvate (R*OH = (+)-N-methylephedrine) in hexane/ether as solvent produces the corresponding 2-hydroxy-2-methylbutan
Stereoselective biocatalytic synthesis of (S)-2-hydroxy-2-methylbutyric acid via substrate engineering by using "thio-disguised" precursors and oxynitrilase catalysis
Fechter, Martin H.,Gruber, Karl,Avi, Manuela,Skranc, Wolfgang,Schuster, Christian,Poechlauer, Peter,Klepp, Kurt O.,Griengl, Herfried
, p. 3369 - 3376 (2008/01/06)
3-Tetrahydrothiophenone (4) and 4-phenylthiobutan-2-one (7) were used as masked 2-butanone equivalents to give the corresponding cyanohydrins 5 (79% yield, 91% ee) and 8 (95% yield, 96% ee) in an enzymatic cyanohydrin reaction applying the hydroxynitrile
Practical enantioselective synthesis of a COX-2 specific inhibitor
Tan, Lushi,Chen, Cheng-Yi,Chen, Weirong,Frey, Lisa,King, Anthony O,Tillyer, Richard D,Xu, Feng,Zhao, Dalian,Grabowski, Edward J.J,Reider, Paul J,O'Shea, Paul,Dagneau, Philippe,Wang, Xin
, p. 7403 - 7410 (2007/10/03)
Two synthetic strategies to the COX-2 specific inhibitor 1 have been described that allowed its preparation in large quantities in 79% overall yield from (S)-2-hydroxy-2-methylbutyric acid. These studies have led to the identification of an efficient resolution of (±)-2-hydroxy-2-methylbutyric acid and a novel thionyl chloride aided formation of amide 11 from acid 6.