37510-22-8Relevant academic research and scientific papers
Silica gel-promoted new one-pot procedure for the synthesis of 1,3-oxathiolan-5-one
Thakare, Manoj P.,Shaikh, Rahimullah,Tayade, Dipak
, p. 465 - 474 (2017)
A highly selective two-component silica gel-promoted synthesis of 1,3-oxathiolan-5-one derivatives in N,N-Dimethylformamide (DMF) is presented. The reaction was carried out using aromatic aldehyde and mercaptoacetic acid in the presence of silica gel in DMF with heating. The reactions were worked up by separating the silica gel and recovering the solid product after adding water in excellent yields without any chromatographic purification. Structures of the compounds were satisfactorily confirmed by 1H NMR and LCMS spectral analysis.
A facile and effective procedure for the synthesis of 4-thiazolidinone derivatives using Y(OTf)3 as catalyst
Luo, Juan,Zhong, Zijun,Ji, Hongfu,Chen, Jiayin,Zhao, Jun,Zhang, Furen
, p. 438 - 449 (2016/07/23)
ABSTRACT: A one-pot three-component reaction for the synthesis of 4-thiazolidinone derivatives has been established by reacting readily available and inexpensive starting materials of amines, aldehydes and thioglycolic acid using Y(OTf)3 (5 mol%) as catalyst in tetrahydrofuran. This method is very efficient due to low catalyst loading and mild reaction conditions and provides an efficient and promising synthetic strategy for the construction of the thiazolidinone skeleton.
Cobalt doped ZnS nanoparticles as a recyclable catalyst for solvent-free synthesis of heterocyclic privileged medicinal scaffolds under infrared irradiation
Dandia, Anshu,Parewa, Vijay,Gupta, Shyam L.,Rathore, Kuldeep S.
, p. 61 - 71 (2013/06/26)
This paper reports preparation and characterization of cobalt doped ZnS NPs and their catalytic application in the synthesis of heterocyclic privileged medicinal scaffolds involving pyrazolones (with excellent regioselectivity) and 1,3-oxathiolan-5-one frameworks under infrared irradiation. Nanoparticles have been prepared at room temperature by a wet chemical method. The heterogeneous catalysts were fully characterized by XRD, TEM, EDAX, ICP-AES and UV/Vis. Under infrared radiation (IR), the catalytic activity of Co doped ZnS NPs was about 40-fold higher under IR as compared to the conventional method. Nanocatalyst plays a dual role of catalyst as well as susceptor, and enhances the overall capacity to absorb IR in the reaction mixture. Doping by Co promotes the activity and selectivity of ZnS NPs as indicated by their high TOF value, providing the products with good to excellent yields. The surface acidity of NPs was measured by FTIR spectra of chemisorbed pyridine. The present method does not involve any hazardous organic solvent or catalyst. The introduction of nanocatalyst in an IR system offers promising features for the reaction response such as the shorter reaction time, simple work-up procedure, and purification of products by non-chromatographic methods. The catalyst was reused up to four runs without an appreciable loss of catalytic activity.
Molecular iodine in [bmim][BF4]: A highly efficient green catalytic system for one-pot synthesis of 1,3-oxathiolan-5-one
Dewan, Manika,Kumar, Ajeet,Saxena, Amit,De, Arnab,Mozumdar, Subho
experimental part, p. 6108 - 6110 (2011/01/04)
Aldehydes and mercaptoacetic acid are coupled in the presence of a catalytic amount of economical and non-toxic molecular iodine in [bmim][BF 4] ionic liquid under mild conditions to afford the corresponding 1,3-oxathiolan-5-one in excellent yields. Molecular iodine acts faster in ionic liquids when compared to conventional solvents such as DMSO, DMF, ethyl acetate, and acetonitrile. The recovered ionic liquids can be recycled in subsequent reactions with consistent activity.
