37519-09-8

Upstream product

• 454-81-9 2-amino-4-(trifluoromethyl)phenol 

Downstream Products

• 854472-72-3 3-bromo-5-(trifluoromethyl)benzene-1,2-diol 
• 1344113-55-8 4-(trifluoromethyl)-1,2-phenylene diacetate 
• 854472-78-9 9-[(E)-7-({[2,2-bis(4-methoxyphenyl)-6-(trifluoromethyl)-1,3-benzodioxol-4-yl]carbonyl}amino)-5,6,7-trideoxy-2,3-O-(1-methylethylidene)-β-D-ribo-hept-5-enofuranosyl]-9H-purin-6-amine 
• 854472-77-8 2,2-bis(4-methoxyphenyl)-6-(trifluoromethyl)-1,3-benzodioxole-4-carboxylic acid 
• 854472-76-7 methyl 2,2-bis(4-methoxyphenyl)-6-(trifluoromethyl)-1,3-benzodioxole-4-carboxylate 
• 854472-74-5 methyl 2,3-bis(phenylmethoxy)-5-(trifluoromethyl)benzoate 
• 854472-73-4 1-bromo-2,3-bis(phenylmethoxy)-5-(trifluoromethyl)benzene 
• 854472-75-6 methyl 2,3-dihydroxy-5-(trifluoromethyl)benzoate 

Relevant academic research and scientific papers

Dearomatization of Electron-Deficient Phenols to ortho-Quinones: Bidentate Nitrogen-Ligated Iodine(V) Reagents

Despite their broad utility, the synthesis of ortho-quinones remains a significant challenge, in particular, access to electron-deficient derivatives remains an unsolved problem. Reported here is the first general method for the synthesis of electron-deficient ortho-quinones by direct oxidation of phenols. The reaction is enabled by a novel bidentate nitrogen-ligated iodine(V) reagent, a previously unexplored class of compounds which we have termed Bi(N)-HVIs. The reaction is extremely general and proceeds with excellent regioselectivity for the ortho over para isomer. Functionalization of the ortho-quinone products was examined, resulting in a facile one-pot synthesis of catechols, as well as the incorporation of a variety of heteroatom nucleophiles. This method represents the first synthetic application of Bi(N)-HVIs and demonstrates their potential as a platform for the further development of highly reactive, but also highly tunable, I(V) reagents.

Synthesis of catechols from phenols via Pd-catalyzed silanol-directed C-H oxygenation

A silanol-directed, Pd-catalyzed C-H oxygenation of phenols into catechols is presented. This method is highly site selective and general, as it allows for oxygenation of not only electron-neutral but also electron-poor phenols. This method operates via a silanol-directed acetoxylation, followed by a subsequent acid-catalyzed cyclization reaction into a cyclic silicon-protected catechol. A routine desilylation of the silacyle with TBAF uncovers the catechol product.

Derivatives of 4-(trifluoromethyl)-phenol and 4-(trifluoromethylphenyl)-2-(tetrahydropyranyl) ether and method for producing the same

The invention relates to a method for producing 2- and 2,5-substituted derivatives of 4-(trifluoromethyl)-phenol and 4-(2-trifluoromethyl)-phenyl)-2-tetrahydropyranyl) ether and to novel derivatives. Said method is characterised in that a compound of form

Novel Synthesis Modes and Properties of Benzodioxinopyridazines

A simple synthesis involving fusion of catechol and derivatives with 3,4,5-trichloropyridazine has furnished 4-chlorobenzodioxinopyridazines 5 for the first time.This new method complements the previously reported base promoted procedure for p