37526-42-4 Usage
Description
2,4,5-trimethyl-2,4-dihydro-3H-1,2,4-triazole-3-thione is a heterocyclic compound with the molecular formula C5H8N2S. It is a derivative of 1,2,4-triazole, which has a thiocarbonyl group attached to the third carbon atom. This chemical is known for its high stability and resistance to hydrolysis, making it a valuable building block in organic synthesis.
Uses
Used in Pharmaceutical Industry:
2,4,5-trimethyl-2,4-dihydro-3H-1,2,4-triazole-3-thione is used as a potential inhibitor of metalloenzyme carbonic anhydrase for its ability to interact with metalloenzymes, which can have therapeutic applications.
Used in Agricultural Industry:
2,4,5-trimethyl-2,4-dihydro-3H-1,2,4-triazole-3-thione is used as a precursor for the synthesis of various bioactive compounds, which can be utilized in the development of agrochemicals and pesticides.
Used in Cancer Research:
2,4,5-trimethyl-2,4-dihydro-3H-1,2,4-triazole-3-thione is used as a potential anti-cancer agent due to its studied properties that suggest it may have an impact on cancer cell growth and proliferation.
Used in Inflammation Treatment:
2,4,5-trimethyl-2,4-dihydro-3H-1,2,4-triazole-3-thione is used as a potential anti-inflammatory agent, indicating its possible role in reducing inflammation and related symptoms.
Used in Organic Synthesis:
2,4,5-trimethyl-2,4-dihydro-3H-1,2,4-triazole-3-thione is used as a valuable building block in organic synthesis due to its high stability and resistance to hydrolysis, which makes it suitable for the creation of complex organic molecules.
Check Digit Verification of cas no
The CAS Registry Mumber 37526-42-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,7,5,2 and 6 respectively; the second part has 2 digits, 4 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 37526-42:
(7*3)+(6*7)+(5*5)+(4*2)+(3*6)+(2*4)+(1*2)=124
124 % 10 = 4
So 37526-42-4 is a valid CAS Registry Number.
37526-42-4Relevant articles and documents
A Study of the Behaviour of 2,4-Substituted Thiosemicarbazides toward Orthoesters: Formation of Mesoionic Compounds
Buccheri, Francesco,Cusmano, Giuseppe,Gruttadauria, Michelangelo,Noto, Renato,Werber, Giuseppe
, p. 1447 - 1451 (2007/10/03)
The reactions beetwen 2,4-disubstituted thiosemicarbazides and orthoesters in refluxing xylene led to the formation of the 1,2,4-triazoline-5-thione ring and to the 1,2,4-triazolium-5-thiolate ring. The formation of the mesoionic componds is due to rearrangement of the easily available 2,4-disubstituted thiosemicarbazides to 1,4-disubstituted thiosemicarbazides under the reaction conditions adopted. This method can be usefully used for the synthesis of mesoionic compounds, especially in the case of the 2-methyl-4-phenylthiosemicarbazide.
SYNTHESIS OF PYRAZOLE, 1,3,4-THIADIAZOLE, AND 1,2,4-TRIAZOLE DERIVATIVES BY CONDENSATION OF 1,3-DIOXO COMPOUNDS WITH THIOSEMICARBAZIDE DERIVATIVES
Zelenin, K. N.,Solod, O. V.,Alekseev, V. V.,Pekhk, T. I.,Kuznetsova, O. B.,et al.
, p. 1051 - 1060 (2007/10/02)
The reaction of β-diketones with 2-unsubstituted thiosemicarbazides leads to the formation of the corresponding 1-thiocarbamoyl-5-hydroxy-2-pyrazolines, which readily undergo aromatization to give pyrazoles, while the reaction of benzoylacetaldehyde leads to the formation of the corresponding hydrazone.Acetylacetone 2-methyl- and 2,4-dimethylthiosemicarbazones are inclined to undergo tautomerization and, depending on the conditions, can exist in enehydrazine, hydrazone, 1,2,4-triazoline, and 1,3,4-thiadiazoline forms or mixtures of these forms.Upon heating these substances are converted to mixtures of the 1,3,5-trimethylpyrazole and the corresponding 1,2,4-triazoline-5-thione.The structures of the compounds were studied by means of IR and 1H, 13C, and 15N NMR spectroscopy and mass spectrometry.
