37528-25-9Relevant academic research and scientific papers
Structure and Dynamics of Hydrogen Chelates: Part 1. NMR-Spectroscopic Studies in the Quinazoline-2-acetonitrile Series
Gehring, Holger,Daltrozzo, Ewald
, p. 236 - 250 (2007/10/03)
To get informations on both the structure and dynamics of hydrogen chelates 1 of heteroaromatic systems, a great variety of quinazoline-2-acelonitrile chelates were synthesized (see 2-4). Similarly to the situation of the corresponding H-chelates in the p
Central Nervous System Active Compounds. XIV On the Cyclization of N-Acyl-N'-arylureas
Heinicke, Grant,Hung, Tran V.,Prager, Rolf H.,Ward, A. David
, p. 831 - 844 (2007/10/02)
The cyclization of N-acyl-N'-arylureas in polyphosphoric acid has been reinvestigated.The product is not only the 4-substituted quinazolin-2(1H)-one as reported, but also contains the 2-acylaniline in major proportions.Two minor products have also been isolated.At 80 deg, an intermediate has been detected, the properties of which are consistent with it being the corresponding 2-acylphenylurea.Acyl ureas with strongly electron-withdrawing acyl groups from major amount of the corresponding anilide by the formal loss of cyanic acid.The application of this reaction tothe synthesis of quinazolinylphthalides has been investigated.
