37530-35-1

Usage

Uses

Used in Pharmaceutical Industry:
5-(3-HYDROXY-BENZYLIDENE)-2-THIOXO-THIAZOLIDIN-4-ONE is used as a pharmaceutical candidate for its potential therapeutic applications in treating various diseases. Its anti-inflammatory and antioxidant properties make it a promising agent for disease management and treatment.
Used in Cancer Treatment:
In the field of oncology, 5-(3-HYDROXY-BENZYLIDENE)-2-THIOXO-THIAZOLIDIN-4-ONE is used as a potential anticancer agent. Its biological activities suggest that it may have the ability to target and inhibit the growth of cancer cells, making it a valuable compound for further research and development in cancer therapy.
Used in Diabetes Management:
5-(3-HYDROXY-BENZYLIDENE)-2-THIOXO-THIAZOLIDIN-4-ONE is also used as a potential therapeutic agent in diabetes management. Its potential biological activities may contribute to the regulation of blood sugar levels and the management of diabetes-related complications.
Used in Drug Development:
Due to its unique structural features and potential biological activities, 5-(3-HYDROXY-BENZYLIDENE)-2-THIOXO-THIAZOLIDIN-4-ONE is used as a starting point for drug development. Researchers in medicinal chemistry can utilize its properties to design and synthesize new drugs with improved efficacy and selectivity for various therapeutic applications.
Used in Medicinal Chemistry Research:
5-(3-HYDROXY-BENZYLIDENE)-2-THIOXO-THIAZOLIDIN-4-ONE serves as a valuable compound in medicinal chemistry research. Its potential biological activities and structural features provide a foundation for exploring new drug targets, mechanisms of action, and optimization strategies to develop more effective and safer therapeutic agents.

InChI:InChI=1/C10H7NO2S2/c12-7-3-1-2-6(4-7)5-8-9(13)11-10(14)15-8/h1-5,12H,(H,11,13,14)/b8-5+

Upstream product

• 141-84-4 2-thioxo-4-thiazolidinone 
• 100-83-4 meta-hydroxybenzaldehyde 

Relevant academic research and scientific papers

Privileged scaffolds or promiscuous binders: A comparative study on rhodanines and related heterocycles in medicinal chemistry

Rhodanines and related five-membered heterocycles with multiple heteroatoms have recently gained a reputation of being unselective compounds that appear as "frequent hitters" in screening campaigns and therefore have little value in drug discovery. However, this judgment appears to be based mostly on anecdotal evidence. Having identified various rhodanines and related compounds in screening campaigns, we decided to perform a systematic study on their promiscuity. An amount of 163 rhodanines, hydantoins, thiohydantoins, and thiazolidinediones were synthesized and tested against several targets. The compounds were also characterized with respect to aggregation and electrophilic reactivity, and the binding modes of rhodanines and related compounds in published X-ray cocrystal structures were analyzed. The results indicate that the exocyclic, double bonded sulfur atom in rhodanines and thiohydantoins, in addition to other structural features, offers a particularly high density of interaction sites for polar interactions and hydrogen bonds. This causes a promiscuous behavior at concentrations in the "screening range" but should not be regarded as a general knockout criterion that excludes such screening hits from further development. It is suggested that special criteria for target affinity and selectivity are applied to these classes of compounds and that their exceptional and potentially valuable biomolecular binding properties are consequently exploited in a useful way.

Synthesis and characterization of (Z)-5-arylmethylidenerhodanines with photosynthesis-inhibiting properties

A series of rhodanine derivatives was prepared. The synthetic approach, analytical and spectroscopic data of all synthesized compounds are presented. Lipophilicity of all the discussed rhodanine derivatives was analyzed using the RP-HPLC method. The compo

Selective small molecule inhibitors of the potential breast cancer marker, human arylamine N-acetyltransferase 1, and its murine homologue, mouse arylamine N-acetyltransferase 2

The identification, synthesis and evaluation of a series of rhodanine and thiazolidin-2,4-dione derivatives as selective inhibitors of human arylamine N-acetyltransferase 1 and mouse arylamine N-acetyltransferase 2 is described. The most potent inhibitors

Microwave induced synthesis of the thiazolidine-2,4-dione motif and the efficient solvent free-solid phase parallel syntheses of 5-benzylidene- thiazolidine-2,4-dione and 5-benzylidene-2-thioxo-thiazolidine-4-one compounds

Novel microwave induced method for the synthesis of thiazolidine-2,4-dione motif under solvent phase conditions is developed. Further we report an efficient, microwave assisted method for the parallel syntheses of biologically important 5-benzylidene-thiazolidine-2,4-dione and 5-benzylidene-2- thioxothiazolidine-4-one compounds under solid-phase and solvent-free conditions. A comparative study between the developed microwave methods and the conventional methods is described. We have also illustrated the possible mechanism behind to address the reason why piperidine, acetic acid and silica gel enhanced the Knoevenagel condensation reaction.

COMPOUNDS USEFUL AS HYPOGLYCEMIC AGENTS AND FOR TREATING ALZHEIMER'S DISEASE

Provided are methods for treating hyperglycemia and Alzheimer's disease utilizing certain rhodanine derivatives. Certain of the rhodanine derivatives utilized in the instant methods are novel and, accordingly, such compounds and pharmaceutical formulation