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Bertilimumab is a monoclonal antibody that specifically targets and inhibits the activity of eotaxin-1, a chemokine that plays a crucial role in the recruitment of eosinophils to areas of inflammation. Eosinophils, a type of white blood cell, are involved in allergic and autoimmune responses, and their excessive activation can result in tissue damage and inflammation. By neutralizing eotaxin-1, bertilimumab aims to decrease eosinophil infiltration into inflamed tissues, thus reducing the inflammatory response associated with various conditions.

375348-49-5

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375348-49-5 Usage

Uses

Used in Allergy and Autoimmune Response Management:
Bertilimumab is used as an immunomodulatory agent for managing allergic and autoimmune responses by reducing eosinophil-mediated inflammation. This makes it a potential treatment for conditions characterized by eosinophilic inflammation, such as asthma, atopic dermatitis, and inflammatory bowel disease.
Used in Asthma Treatment:
In the field of respiratory medicine, bertilimumab is used as a therapeutic agent for treating severe asthma, particularly in patients with elevated eosinophil levels. It helps in reducing asthma exacerbations and improving lung function by targeting the eosinophilic inflammation that contributes to the disease's severity.
Used in Atopic Dermatitis Treatment:
In dermatology, bertilimumab is used as a treatment for atopic dermatitis, an inflammatory skin condition. By inhibiting eotaxin-1, it reduces eosinophil infiltration into the skin, which can help alleviate symptoms such as itching, redness, and swelling.
Used in Inflammatory Bowel Disease Treatment:
In gastroenterology, bertilimumab is used as a potential treatment for inflammatory bowel diseases, such as Crohn's disease and ulcerative colitis. It targets the eosinophilic inflammation that plays a role in the pathogenesis of these conditions, potentially leading to a reduction in disease activity and improvement in patient outcomes.

Check Digit Verification of cas no

The CAS Registry Mumber 375348-49-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,7,5,3,4 and 8 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 375348-49:
(8*3)+(7*7)+(6*5)+(5*3)+(4*4)+(3*8)+(2*4)+(1*9)=175
175 % 10 = 5
So 375348-49-5 is a valid CAS Registry Number.

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