37536-65-5Relevant academic research and scientific papers
Diols, α-Ketols, and Diones as 22π Components in [2+2+2] Cycloadditions of 1,6-Diynes via Ruthenium(0)-Catalyzed Transfer Hydrogenation
Sato, Hiroki,Bender, Matthias,Chen, Weijie,Krische, Michael J.
, p. 16244 - 16247 (2016)
The first use of vicinal diols, ketols, or diones as 22π components in metal-catalyzed [2+2+2] cycloaddition is described. Using ruthenium(0) catalysts, 1,6-diynes form ruthenacyclopentadienes that engage transient diones in successive carbonyl addition. Transfer hydrogenolysis of the resulting ruthenium(II) diolate mediated by the diol or ketol reactant releases the cycloadduct with regeneration of ruthenium(0) and the requisite dione.
Synthesis of a heterocyclic aza-enediyne and its DNA-cleavage properties
David, Wendi M.,Kumar, Dalip,Kerwin, Sean M.
, p. 2509 - 2512 (2000)
The benzimidazolium salt 2, incorporating an aza-enediyne moiety, has been prepared and is shown to be a very effective DNA-cleavage agent under mild physiological conditions. Its mechanism of action is currently under investigation but may involve the generation of a diradical intermediate, DNA alkylation, or both. (C) 2000 Elsevier Science Ltd.
