37539-91-6

Upstream product

• 36286-76-7 ethyl 5-oxo-3-phenyl-4,5-dihydro-1,2,4-triazine-6-carboxylate 
• 921620-61-3 5-oxo-3-phenyl-5,6-dihydro-[1,2,4]triazine-6-carboxylic acid ethyl ester 
• 28819-30-9 benzamidrazone 
• 1670-14-0 benzamidine monohydrochloride 
• 36286-76-7 5-oxo-3-phenyl-4,5-dihydro-[1,2,4]triazine-6-carboxylic acid ethyl ester 

Downstream Products

• 126542-43-6 3-Phenyl-[1,2,4]triazine-6-carboxylic acid ethyl ester 
• 572920-57-1 5-amino-3-phenyl-1,2,4-triazine-6-carboxamide 
• 37539-92-7 ethyl 5-amino-3-phenyl-1,2,4-triazine-6-carboxylate 
• 126542-55-0 5-But-3-ynyloxy-3-phenyl-[1,2,4]triazine-6-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

INHIBITORS OF MITOTIC KINESIN

The present invention relates to compounds useful as inhibitors of KSP and methods for the treatment or prevention of cellular proliferative diseases.

Novel 6-azapteridines from bifunctional 1,2,4-triazines

The convergent synthesis of ethyl 5-chloro- and 5-amino-3-aryl-1,2,4-triazinecarboxylates 9a-9d and 10a-10d as well as of 5-amino-3-aryl-1,2,4-triazine-6-carboxamides 11a-11d is described. Compounds 9, 10 and 11 are powerful key compounds for cyclization reactions to the novel pyrimido[4,5-e][1,2,4]triazines 13d, 14c, 14d, 15c and 17a, 17d.

The Chemistry of 1,2,4-Triazines, XIV. - Synthesis and Reactions of 5-Chloro-1,2,4-triazines

5-Chloro-1,2,4-triazines 4 are prepared from 1,2,4-triazin-5(2H)-ones 3 and transfered into 5-amino- (7), 5-cyano (8), and 5-(ω-alkinyloxy)-1,2,4-triazines (9). 7a-d are cyclized to imidazo1,2,4-triazines (10a-d).