37543-38-7Relevant academic research and scientific papers
From Alkenes to Isoxazolines via Copper-Mediated Alkene Cleavage and Dipolar Cycloaddition
Gao, Mingchun,Gan, Yuansheng,Xu, Bin
supporting information, p. 7435 - 7439 (2019/10/08)
An unprecedented copper-mediated anion transformation is reported, along with selective C= C double bond cleavage and dipolar cycloaddition reaction from simple alkenes and inexpensive copper nitrate. Various transformations demonstrate the generality of this method. Further mechanistic investigation indicates a novel ionic pathway for alkene cleavage and highlights the coeffect of iodide and boric acid as additives on the inhibition of well-documented competitive nitration byproducts.
Copper Nitrate Mediated Regioselective [2+2+1] Cyclization of Alkynes with Alkenes: A Cascade Approach to Δ2-Isoxazolines
Gao, Mingchun,Li, Yingying,Gan, Yuansheng,Xu, Bin
supporting information, p. 8795 - 8799 (2015/11/27)
An efficient method for the regioselective synthesis of pharmacologically relevant polysubstituted Δ2-isoxazolines is based on the copper-mediated direct transformation of simple terminal alkynes and alkenes. The overall process involves the formation of four chemical bonds with inexpensive and readily available copper nitrate trihydrate as a novel precursor of nitrile oxides. The reaction can be easily handled and proceeds under mild conditions.
