37551-43-2

Usage

Uses

Used in Anticancer Applications:
5-Chloro-N,2-dihydroxybenzamide is used as an anticancer agent for its potential to modulate several oncological signaling pathways, exerting inhibitory effects on tumor growth and progression. Its potential synergistic anticancer effects when combined with conventional chemotherapeutic drugs could enhance chemo-sensitivity and efficacy in resistant cases.
Used in Food Industry:
5-Chloro-N,2-dihydroxybenzamide is used as a flavor compound in the food industry, particularly in roasted coffee, where it contributes to the taste and aroma. The chlorination process of this chemical affects the overall flavor profile of the coffee, making it an important component in the development of coffee products.
Used in Pharmaceutical Research:
5-Chloro-N,2-dihydroxybenzamide is used as a research compound in the pharmaceutical industry for its potential antioxidant and anticancer properties. Further comprehensive research is necessary to understand its detailed properties, molecular formula, molar mass, melting or boiling points, and other safety or hazard information, which could lead to the development of new therapeutic applications.

InChI:InChI=1/C7H6ClNO3/c8-4-1-2-6(10)5(3-4)7(11)9-12/h1-3,10,12H,(H,9,11)

Upstream product

• 321-14-2 5-chloro-2-hydroxybenzoic acid 
• 4068-78-4 methyl 5-chloro-2-hydroxybenzoate 

Downstream Products

• 95-25-0 5-chloro-2-benzoxazolinone 
• 24603-63-2 5-chloro-3-hydroxy-1,2-benzoisoxazole 
• 29053-27-8 7-chloro-2c-methyl-(3ar)-3,3a-dihydro-2H-benzo[e]isoxazolo[3,2-b][1,3]oxazin-9-one 
• 29053-27-8 7-chloro-2t-methyl-(3ar)-3,3a-dihydro-2H-benzo[e]isoxazolo[3,2-b][1,3]oxazin-9-one 
• 29050-11-1 7-chloro-3,3a-dihydro-2H-benzo[e]isoxazolo[3,2-b][1,3]oxazin-9-one 
• 16263-53-9 3,5-dichloro-1,2-benzoisoxazole 
• 24603-63-2 5-Chloro-benzo[d]isoxazol-3-one 
• 63482-60-0 6-chloro-2-(2-chloro-propyl)-3-hydroxy-2,3-dihydro-benzo[e][1,3]oxazin-4-one 
• 29050-04-2 6-chloro-2-(2-chloro-ethyl)-3-hydroxy-2,3-dihydro-benzo[e][1,3]oxazin-4-one 

Relevant academic research and scientific papers

Family of mixed 3d-4f dimeric 14-metallacrown-5 compounds: Syntheses, structures, and magnetic properties

An isomorphous family of mixed 3d-4f dodenuclear aggregates, {[Mn III8Ln4(Clshi)8(OAc) 6(μ3-OCH3)2(μ3-O) 2(CH3OH)12(H2O)2] ·4CH3OH·xH2O)} (where Ln = EuIII (1), GdIII (2), TbIII (3), and DyIII (4); ClshiH3 = 5-chlorosalicylhydroxamic acid; x = 5 for 1 and 3; x = 6 for 2; x = 2 for 4), were synthesized and characterized. They were obtained from the reaction of ClshiH3 with Mn(OAc)2·4H 2O and Ln(NO3)3·6H2O. These isomorphous mixed 3d-4f compounds represent a family of novel structures with lanthanide ions in the metallacrown (MC) ring. Each dodecanuclear aggregate contains two offset stacked 14-MC-5 units with M-N-O-M-N-O-Ln-O-N-M-O-N-M connectivity to capture one LnIII ion in the core of each MC. Two 14-MC-5 units are connected through O ions with four Mn ions and six O atoms arranged in a double Mn4O6 cubane. Magnetic measurement indicates that antiferromagnetic interactions are present between the metal ions. The DyIII analogue with high anisotropy and large spin shows slow magnetization relaxation at a direct-current field of 2 kOe.

Synthesis and Biological Evaluation of 1-(1,2-Benzisothiazol-3-yl)- and (1,2-Benzisoxazol-3-yl)piperazine Derivatives as Potential Antipsychotic Agents

Members of the series of title compounds were tested for potential antipsychotic activity in relevant receptor binding assays and behavioral screens.Structure-activity relationships within the series are discussed.Compound 24 (BMY 13859-1), a (1,2-benzisothiazol-3-yl)piperazine derivative, was selected for further study because of its potent and selective profile in primary CNS tests.It was active in the Sidman avoidance paradigm and blocked amphetamine-induced stereotyped behavior in dogs for up to 7 h.The compound's lack of typical neuroleptic-like effects in therat catalepsy test and its failure to produce dopamine receptor supersensitivity following chronic administration indicate that it should not cause the movement disorders commonly associated with antipsychotic therapy.Although 24 has potent affinity for dopaminergic binding sites, its even greater affinity for serotonin receptors suggests that a serotonergic component may be relevant to its atypical profile.Compound 24 is currently undergoing clinical evaluation in schizophrenic patients.

Method for lowering serum uric acid

A method for lowering serum uric acid is disclosed which comprises administering to a human for its uricosuric activity a pharmaceutical composition comprising 7-chloro-2-methyl-3,3a-dihydro-2H,9H-isoxazolo (3,2-b) (1,3)-benzoxazin-9-one. 7-chloro-2-methyl-3,3a-dihydro-2H,9H-isoxazolo (3,2-b) (1,3) benzoxazin-9-one is a useful compound having valuable pharmacological properties, for example, it is a valuable anti-inflammatory agent, as evidenced by its ability to inhibit the local edema formation characteristic of inflammatory states when administered systemically to warm-blooded animals.

Chemical process for preparation of 7-chloro-2-methyl-3,3a-dihydro-2H,9H-isoxazolo(3,2-b)(1,3)-benzoxazin-9-one

The compound 7-chloro-2-methyl-3,3a-dihydro-2H,9H-isoxazolo(3,2-b)(1,3)-benzoxazin-9-one is produced by reacting a mixture of tetrahydrofuran and crotonaldehyde with 5-chlorosalicylhydroxamic acid. The compound has demonstrated utility as a uricosuric agent.