37568-82-4

Upstream product

• 1093748-41-4 methyl 2-(tert-butyldimethylsilyloxy)-6-(bromomethyl)-benzoate 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 63368-34-3 (3,4-dimethoxybenzyl)triphenylphosphonium chloride 
• 53015-08-0 2-formyl-6-methoxy-benzoic acid 
• 77-78-1 dimethyl sulfate 
• 858847-55-9 3,3',4'-trimethoxystilbene-2-carboxylic acid 

Downstream Products

• 93-07-2 Veratric acid 
• 80394-88-3 Thunberginol G 

Relevant academic research and scientific papers

Titanocene(III) chloride mediated radical-induced synthesis of 3,4-dihydroisocoumarins: synthesis of (±)-hydrangenol, (±)-phyllodulcin, (±)-macrophyllol and (±)-thunberginol G

A radical-promoted synthesis of 3,4-dihydroisocoumarins has been achieved in moderate to good yields using titanocene(III) chloride (Cp2TiCl) as the radical initiator. The total synthesis of four naturally occurring dihydrocoumarins hydrangenol, phyllodulcin, macrophyllol and thunberginol G has been accomplished using the radical technology. Cp2TiCl was prepared in situ from commercially available titanocene dichloride (Cp2TiCl2) and Zn-dust in THF under argon.

Convenient syntheses of 3-aryl-3,4-dihydroisocoumarins and lunularic acid derivatives

A convenient two-step approach for the syntheses of 3-aryl-3,4-dihydroisocoumarins (13-17) including some naturally occurring 3-aryl-8-hydroxy-3,4-dihydroisocoumarins (1,2) and lunularic acid derivatives (18-21) is described from 2-formylbenzoic acids (4,