375792-83-9Relevant academic research and scientific papers
Towards synthetic adrenaline receptors - Shape-selective adrenaline recognition in water
Herm, Michael,Molt, Oliver,Schrader, Thomas
, p. 3148 - 3151 (2001)
A new rationally designed receptor molecule binds adrenaline derivatives in water. Its binding pattern (see picture) imitates the interplay of noncovalent interactions operating in the natural receptor. High shape selectivity is achieved for the slim dopamine skeleton, and leads to rejection of substrates with an a-substituent, such as amino acid derivatives.
Towards synthetic adrenaline receptors - Shape-selective adrenaline recognition in water
Herm, Michael,Molt, Oliver,Schrader, Thomas
, p. 1485 - 1499 (2007/10/03)
In spite of their key role in signal transduction, the mechanism of action of adrenergic receptors is still poorly understood. We have imitated the postulated binding pattern of the large membrane protein with a small, rationally designed synthetic host molecule. Experimental evidence is presented for the simultaneous operation of electrostatic attraction, hydrogen bonds, π stacking, and hydrophobic interactions. By virtue of this combination of weak attractive forces, adrenaline derivatives in water are bound with high shape selectivity for the slim dopamine skeleton. We think that these findings support the postulated cooperative interplay of noncovalent interactions in the natural receptors. In addition, they provide access to a new type of adrenaline sensor. This may be the first step towards an artificial signal-transduction system.
