375823-41-9
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Basic information
- Product Name: TocilizuMab
- Synonyms: TocilizuMab;Actemra;Actemra 200;Atlizumab;R 1569;RoActemra;Tocilizumab,Atlizumab
- CAS NO:375823-41-9
- Molecular Formula: C14H12O3
- Molecular Weight: 228.24328
- EINECS: -0
- Product Categories: API
- Mol File: 375823-41-9.mol
- Article Data: 0
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: /
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: N/A
- Solubility: N/A
- CAS DataBase Reference: TocilizuMab(CAS DataBase Reference)
- NIST Chemistry Reference: TocilizuMab(375823-41-9)
- EPA Substance Registry System: TocilizuMab(375823-41-9)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 375823-41-9(Hazardous Substances Data)
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375823-41-9 Usage
Clinical Use
Interleukin inhibitor: Treatment of rheumatoid arthritis in combination with methotrexateDrug interactions
Potentially hazardous interactions with other drugs Live vaccines: avoid concomitant administrationMetabolism
Tocilizumab undergoes biphasic elimination from the circulation. The total clearance of tocilizumab is concentration-dependent and is the sum of the linear and non-linear clearance. The concentration-dependent non-linear clearance plays a major role at low tocilizumab concentrations. Once the non-linear clearance pathway is saturated, at higher tocilizumab concentrations, clearance is mainly determined by the linear clearance.Check Digit Verification of cas no
The CAS Registry Mumber 375823-41-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,7,5,8,2 and 3 respectively; the second part has 2 digits, 4 and 1 respectively.Calculate Digit Verification of CAS Registry Number 375823-41:
(8*3)+(7*7)+(6*5)+(5*8)+(4*2)+(3*3)+(2*4)+(1*1)=169
169 % 10 = 9
So 375823-41-9 is a valid CAS Registry Number.
375823-41-9Upstream product
375823-41-9Downstream Products
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