375824-48-9Relevant academic research and scientific papers
β-Selective glycosylations with masked D-mycosamine precursors
Packard, Garrick K.,Rychnovsky, Scott D.
, p. 3393 - 3396 (2001)
Equation presented Both an intramolecular aglycon delivery (IAD) method and an intermolecular SN2 displacement method were examined for β-selective glycosylations of cholesterol with D-mycosamine. An anomeric sulfoxide, sulfide, selenide, and fluoride were all successfully used as glycosyl donors in IAD reactions. The α-bromo ketone 19 was synthesized from protected mycosamine and employed in an intermolecular SN2 glycosylation reaction. Both routes were successful for the model alcohol, cholesterol.
