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375857-65-1

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  • SAGECHEM/3-Bromo-7-(trifluoromethyl)imidazo[1,2-a]pyrimidine/SAGECHEM/Manufacturer in China

    Cas No: 375857-65-1

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375857-65-1 Usage

Chemical Properties

White to off-white solid

Check Digit Verification of cas no

The CAS Registry Mumber 375857-65-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,7,5,8,5 and 7 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 375857-65:
(8*3)+(7*7)+(6*5)+(5*8)+(4*5)+(3*7)+(2*6)+(1*5)=201
201 % 10 = 1
So 375857-65-1 is a valid CAS Registry Number.
InChI:InChI=1/C7H3BrF3N3/c8-5-3-12-6-13-4(7(9,10)11)1-2-14(5)6/h1-3H

375857-65-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-Bromo-7-(trifluoromethyl)imidazo[1,2-a]pyrimidine

1.2 Other means of identification

Product number -
Other names 3-bromo-7-trifluoromethylimidazo[1,2-a]pyrimidine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:375857-65-1 SDS

375857-65-1Downstream Products

375857-65-1Relevant articles and documents

Imidazo[1,2-a]pyrimidines as functionally selective and orally bioavailable GABAAα2/α3 binding site agonists for the treatment of anxiety disorders

Goodacre, Simon C.,Street, Leslie J.,Hallett, David J.,Crawforth, James M.,Kelly, Sarah,Owens, Andrew P.,Blackaby, Wesley P.,Lewis, Richard T.,Stanley, Joanna,Smith, Alison J.,Ferris, Pushpinder,Sohal, Bindi,Cook, Susan M.,Pike, Andrew,Brown, Nicola,Wafford, Keith A.,Marshall, George,Castro, José L.,Atack, John R.

, p. 35 - 38 (2007/10/03)

A series of high-affinity GABAA agonists with good oral bioavailability in rat and dog and functional selectivity for the GABA Aα2 and -α3 subtypes is reported. The 7-trifluoromethylimidazopyrimidine 14g and the 7-propan-2-olimidazopyrimidine 14k are anxiolytic in both conditioned and unconditioned animal models of anxiety with minimal sedation observed at full BZ binding site occupancy.

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