375857-65-1

Basic information

• Product Name: 3-Bromo-7-(trifluoromethyl)imidazo[1,2-a]pyrimidine
• Synonyms: 3-BROMO-7-(TRIFLUOROMETHYL)IMIDAZO[1,2-A]PYRIMIDINE;3-Bromo-7-(trifluoromethyl)imidazo[1,2-a]pyrimidine ,97%
• CAS NO: 375857-65-1
• Molecular Formula: C₇H₃BrF₃N₃
• Molecular Weight: 266.02
• Product Categories: Fluorine series
• Mol File: 375857-65-1.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• Density: 1.969 g/cm³
• Refractive Index: 1.62
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-Bromo-7-(trifluoromethyl)imidazo[1,2-a]pyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Bromo-7-(trifluoromethyl)imidazo[1,2-a]pyrimidine(375857-65-1)
• EPA Substance Registry System: 3-Bromo-7-(trifluoromethyl)imidazo[1,2-a]pyrimidine(375857-65-1)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 375857-65-1(Hazardous Substances Data)

Usage

Chemical Properties

White to off-white solid

InChI:InChI=1/C7H3BrF3N3/c8-5-3-12-6-13-4(7(9,10)11)1-2-14(5)6/h1-3H

Upstream product

• 149771-18-6 2-Methyl-4-trifluoromethyl-pyrimidine 
• 16075-42-6 2-amino-4-trifluoromethylpyrimidine 

Relevant articles and documents

Imidazo[1,2-a]pyrimidines as functionally selective and orally bioavailable GABAAα2/α3 binding site agonists for the treatment of anxiety disorders

A series of high-affinity GABAA agonists with good oral bioavailability in rat and dog and functional selectivity for the GABA Aα2 and -α3 subtypes is reported. The 7-trifluoromethylimidazopyrimidine 14g and the 7-propan-2-olimidazopyrimidine 14k are anxiolytic in both conditioned and unconditioned animal models of anxiety with minimal sedation observed at full BZ binding site occupancy.