37592-80-6

Upstream product

• 37592-79-3 (4S,4aR,8S,9aR)-3,4-Dibromo-2,2,8-trimethyl-decahydro-4a,8-methano-benzocycloheptene 
• 130216-48-7 (4aR,8S,9aS)-2,8-Dimethyl-octahydro-4a,8-methano-benzocyclohepten-4-one 
• 73211-92-4 8-Methyl-6,7,8,9-tetrahydro-5H-4a,8-methano-benzocyclohepten-2-one 
• 73213-54-4 (4aR,8S,9aR)-2,8-Dimethyl-1,2,5,6,7,8,9,9a-octahydro-4a,8-methano-benzocycloheptene-2-carbonitrile 
• 73211-93-5 (4aS,8R,9aS)-8-Methyl-octahydro-4a,8-methano-benzocyclohepten-2-one 
• 123870-24-6 1β-Methyltricyclo<6.3.1.0^3,8>dodec-3-en-5-on 
• 130216-43-2 2,5-dimethyl-2-(2-methoxycarbonylethyl)-7-methoxyindan-1-one 
• 130216-45-4 2-(3-bromopropyl)-2,6-dimethyl-4-methoxyindane 
• 130216-44-3 2,6-dimethyl-2-(3-hydroxypropyl)-4-methoxyindane 
• 130216-46-5 2-(3-bromopropyl)-2,6-dimethyl-4-hydroxyindane 
• 130216-49-8 (1SR,6SR,8RS)-4,8-dimethyltricyclo[6.3.1.0^1,6]dodec-3-en-2-one 
• 130216-47-6 4,8-dimethyltricyclo[6.3.1.0^1,6]dodeca-3,5-dien-2-one 
• 37592-82-8 (1SR,6RS,8RS)-4,4,8-trimethyltricyclo[6.3.1.0^1,6]dodecan-2-one 
• 130216-42-1 2,5-dimethyl-7-methoxyindan-1-one 

Relevant academic research and scientific papers

A stereoselective total synthesis of (±)-pseudoclovene-B

A stereocontrolled approach to the construction of the tricyclo[6.3.1.01,6]dodecane ring system related to the sesquiterpene pseudoclovene-B (3) is delineated. Starting from the indanone 4, the bromophenol 5 was prepared in a straightforward manner. An aryl participated intramolecular cyclisation of 5 afforded the tricyclic dienone 6 which was stereoselectively converted into the A/B cis-fused ketone 7 through the intermediates 13 and 14 or through the intermediate 15. The tosylhydrazone derivative of 7 was treated with methyl lithium to furnish (±)-pseudoclovene-B in high yield.

Stereocontrolled Total Synthesis of Pseudoclovene-B

An efficient stereocontrolled synthesis of (+/-)-pseudoclovene-B (3) has been accomplished, involving aryl participated intramolecular cyclisation of the bromophenol (10) as the key step.