37603-49-9

Upstream product

• 54722-52-0 2-amino-3-phenyl-3H-indol-3-ol 
• 109-64-8 1,3-dibromo-propane 
• 37603-46-6 C₁₃H₁₄N₂O₂ 
• 91-56-5 indole-2,3-dione 
• 6714-68-7 spiro[1,3-dioxolane-2,3'-indolin]-2'-one 
• 10349-82-3 3-<1'-<2'(1'H)-oxospiro<1,3-dioxolane-2,3'-indol>yl>>propanenitrile 
• 37603-48-8 3,4-dihydro-2H-pyrimido[1,2-a]indol-10-one 

Downstream Products

• 114918-62-6 10-acetamido-2,3,4,10-tetrahydro-10-phenylpyrimido[1,2-a]indole 
• 37647-91-9 1,2,3,4,10,10a-hexahydro-10-phenylpyrimido<1,2-a>indole-10-ol 
• 136650-40-3 1-(3-aminopropyl)-3-hydroxy-3-phenylindol-2(3H)-one hydrochloride 
• 136650-42-5 6-phenyl-1,2,3,4,5,6-hexahydro-1,6-methano-1,5-benzodiazocin-11-one hydrochloride 
• 136650-32-3 6-phenyl-5-(p-tolylsulphonyl)-1,2,3,4,5,6-hexahydro-1,6-methano-1,5-benzodiazocin-11-one 

Relevant academic research and scientific papers

Oral Hypoglycemic Agents. Pyrimidoindoles and Related Compounds

A series of pyrimidoindoles were synthesized and studied for their hypoglycemic activity following oral administration at standard dose of 100 mg/kg to fed rats.The effect of 10-alkoxyalkyl, 10-alkyl, 10-aryl, and 3,3-dialkyl substitution on the activity of 10-hydroxypyrimidoindoles was investigated.Relative potencies of a number of the most active compounds were defined by three-point dose-response studies.The most potent compounds were those with either 3,3-dimethyl substituents, compounds 21, 22, and 38, or 3,3-spirocyclohexane substituents, compounds 39 and 49. 10-Aminopyrimidoindoles were in general less active than the 10-hydroxy analogues, and potency was further decreased by derivatizing the 10-amino group.The most potent 10-amino derivatives were 57 and 58.

Process for the preparation of diazepino[1,2-a]indoles

The invention relates to a process for preparing fused ring indole derivatives of formula (I) SPC1 wherein R1, R2, R3, R4 are each hydrogen, hydroxyl, lower alkyl, lower alkoxy, haloloweralkyl or halogen, R5 and R6 are each hydrogen or lower alkyl and m and n are 0, 1, 2 or 3 and the sum of m + n is 2 or 3, by condensing an indole derivative of formula SPC2 With a dihaloalkane of formula EQU1 The products have pharmacological activity, particularly antidepressant and hypoglycaemic activity.