3761-41-9

Basic information

• Product Name: FENTHION-SULFOXIDE
• Synonyms: MPP SULFOXIDE;MESULFENFOS;FENTHION-SULFOXIDE;FENTHION-SULPHOXIDE;fensulfoxide;mesulfenos;o,o-dimethylo-((4-methylthio)-m-tolyl)phosphorothioatesulfoxide;o,o-dimethylo-(4-(methylsulfinyl)-m-tolyl)phosphorothioate
• CAS NO: 3761-41-9
• Molecular Formula: C₁₀H₁₅O₄PS₂
• Molecular Weight: 294.33
• EINECS: 200-835-2
• Product Categories: Alpha sort;E-GAlphabetic;F;FA - FLPesticides;Insecticides;Organophorous;Pesticides&Metabolites
• Mol File: 3761-41-9.mol
• Article Data: 5

Chemical Properties

• Melting Point: 58～60℃
• Boiling Point: 397.1°C at 760 mmHg
• Flash Point: 2 °C
• Appearance: /
• Density: 1.34g/cm³
• Vapor Pressure: 3.73E-06mmHg at 25°C
• Refractive Index: 1.584
• Storage Temp.: APPROX 4°C
• BRN: 2136026
• CAS DataBase Reference: FENTHION-SULFOXIDE(CAS DataBase Reference)
• NIST Chemistry Reference: FENTHION-SULFOXIDE(3761-41-9)
• EPA Substance Registry System: FENTHION-SULFOXIDE(3761-41-9)

Safety Data

• Hazard Codes: F,Xn,N,T
• Statements: 11-20/21/22-36-50/53-25
• Safety Statements: 16-26-36-60-61-45
• RIDADR: 2783
• WGK Germany: 3
• RTECS: TF9400000
• HazardClass: 6.1(b)
• PackingGroup: III
• Hazardous Substances Data: 3761-41-9(Hazardous Substances Data)

Usage

Uses

Fenthion Sulfoxide is the sulfoxide anlogue and metabolite of the organothiophosphate insecticide Fenthion (F278000).

InChI:InChI=1/C10H15O4PS2/c1-8-7-9(5-6-10(8)17(4)11)14-15(16,12-2)13-3/h5-7H,1-4H3

Upstream product

• 55-38-9 fenthion 

Downstream Products

• 14143-28-3 3-methyl-4-(methylsulfinyl)phenol 

Relevant articles and documents

Human flavin-containing monooxygenase 1 and its long-sought hydroperoxyflavin intermediate

Out of the five isoforms of human flavin-containing monooxygenase (hFMO), FMO1 and FMO3 are the most relevant to Phase I drug metabolism. They are involved in the oxygenation of xenobiotics including drugs and pesticides using NADPH and FAD as cofactors. Majority of the characterization of these enzymes has involved hFMO3, where intermediates of its catalytic cycle have been described. On the other hand, research efforts have so far failed in capturing the same key intermediate that is responsible for the monooxygenation activity of hFMO1. In this work we demonstrate spectrophotometrically the formation of a highly stable C4a-hydroperoxyflavin intermediate of hFMO1 upon reduction by NADPH and in the presence of O2. The measured half-life of this flavin intermediate revealed it to be stable and not fully re-oxidized even after 30 min at 15 °C in the absence of substrate, the highest stability ever observed for a human FMO. In addition, the uncoupling reactions of hFMO1 show that this enzyme is 2O2 with no observable superoxide as confirmed by EPR spin trapping experiments. This behaviour is different from hFMO3, that is shown to form both H2O2 and superoxide anion radical as a result of ～50% uncoupling. These data are consistent with the higher stability of the hFMO1 intermediate in comparison to hFMO3. Taken together, these data demonstrate the different behaviours of these two closely related enzymes with consequences for drug metabolism as well as possible toxicity due to reactive oxygen species.

The role of carbonate radical in limiting the persistence of sulfur-containing chemicals in sunlit natural waters

Carbonate radical (·CO3/-) is a selective oxidant that may be important in limiting the persistence of a number of sulfur-containing compounds in sunlit natural waters. Thioanisole, dibenzothiophene (DBT), and fenthion were selected

Pesticidal compositions in paste form

Novel pasty compositions for the control of animal pests and fungal diseases on plants, which compositions comprise at least one pesticidally active or fungicidally active compound and at least one adjuvant, which is solid, liquid or pasty at room temperature and optionally, one or more excipients and water.