37612-62-7

Upstream product

• 121-69-7 N,N-dimethyl-aniline 
• 155688-82-7 1-crotonoyl-3,5-dimethylpyrazole 

Downstream Products

• 199536-41-9 N-[(1S,2S)-2-(3,5-Dimethyl-pyrazole-1-carbonyl)-1-phenyl-butyl]-4-methyl-benzenesulfonamide 
• 17324-17-3 trans-3-methyl-1,4-diphenylazetidin-2-one 
• 22628-31-5 syn-3-methyl-1,4-diphenylazetidin-2-one 
• 17324-19-5 trans-3-etyl-1,4-diphenyl-azetidin-2-one 
• 17324-18-4 (3S,4S)-3-Ethyl-1,4-diphenyl-azetidin-2-one 

Relevant academic research and scientific papers

Visible-Light-Induced Synthesis of 1,2,3,4-Tetrahydroquinolines through Formal [4+2] Cycloaddition of Acyclic α,β-Unsaturated Amides and Imides with N,N-Dialkylanilines

1,2,3,4-Tetrahydroquinolines should be applicable to the development of new pharmaceutical agents. A facile synthesis of 1,2,3,4-tetrahydroquinolines that is achieved by a photoinduced formal [4+2] cycloaddition reaction of acyclic α,β-unsaturated amides and imides with N,N-dialkylanilines under visible-light irradiation, in which a new IrIII complex photosensitizer, a thiourea, and an oxidant act cooperatively in promoting the reaction, is reported. The photoreaction enables the synthesis of a wide variety of 1,2,3,4-tetrahydroquinolines, while controlling the trans/cis diastereoselectivity (>99:1) and constructing contiguous stereogenic centers. A chemoselective cleavage of an acyclic imide auxiliary is demonstrated.