37613-35-7Relevant academic research and scientific papers
Synthesis and structure-activity relationships of 3,5-diarylisoxazoles and 3,5-diaryl-1,2,4-oxadiazoles, novel classes of small molecule interleukin-8 (IL-8) receptor antagonists
Weidner-Wells, Michele A.,Henninger, Todd C.,Fraga-Spano, Stephanie A.,Boggs, Christine M.,Matheis, Michele,Ritchie, David M.,Argentieri, Dennis C.,Wachter, Michael P.,Hlasta, Dennis J.
, p. 4307 - 4311 (2004)
A novel series of 3,5-diarylisoxazole and 3,5-diaryl-1,2,4-oxadiazole IL-8 inhibitors has been identified. These compounds exhibit activity in an IL-8 binding assay as well as in a functional assay of IL-8 induced elastase release from neutrophils. In add
