37622-61-0

Upstream product

• 99-10-5 3,5-Dihydroxybenzoic acid 
• 111-27-3 hexan-1-ol 
• 28917-43-3 3,5-dibenzyloxybenzoic acid 
• 85593-77-7 2,4-bis(benzyloxy)benzoic acid 
• 111-25-1 1-bromo-hexane 

Relevant academic research and scientific papers

Inhibitory effects of cardols and related compounds on superoxide anion generation by xanthine oxidase

5-Pentadecatrienylresorcinol, isolated from cashew nuts and commonly known as cardol (C15:3), prevented the generation of superoxide radicals catalysed by xanthine oxidase without the inhibition of uric acid formation. The inhibition kinetics did not follow the Michelis-Menten equation, but instead followed the Hill equation. Cardol (C10:0) also inhibited superoxide anion generation, but resorcinol and cardol (C5:0) did not inhibit superoxide anion generation. The related compounds 3,5-dihydroxyphenyl alkanoates and alkyl 2,4-dihydroxybenzoates, had more than a C9 chain, cooperatively inhibited but alkyl 3,5-dihydroxybenzoates, regardless of their alkyl chain length, did not inhibit the superoxide anion generation. These results suggested that specific inhibitors for superoxide anion generation catalysed by xanthine oxidase consisted of an electron-rich resorcinol group and an alkyl chain having longer than C9 chain.

Self-assembling properties of a series of homologous ester-diamides-from ribbons to nanotubes

We have studied the aggregation properties of a series of compounds BHPB-n bearing two amide groups and an ester alkyl chain. The number (n) of carbon atoms in this alkyl chain has been varied from 5 to 16. These compounds form gels at low concentration i

Molecular design of antifungal agents

In a rational approach to the design of antifungal agents against Saccharomyces cerevisiae, a series of alkyl gallates (3,4,5-trihydroxybenzoates) were synthesized and assayed. Nonyl gallate (1) was found to be the most effective with a minimum fungicidal concentration (MFC) of 12.5 μg/mL (42 μM), followed by octyl gallate (2) with an MFC of 25 μg/mL (89 μM). These MFCs are little influenced by pH values. A time-kill curve study indicates that nonyl gallate exhibits fungicidal activity against S. cerevisiae at any growing stage. The antifungal activity of nonyl gallate is due primarily to its ability to act as a nonionic surface-active agent (surfactant). The length of the alkyl group is not a major contributor but plays a role in eliciting the activity to a large extent. As far as alkyl gallates are concerned, their antimicrobial spectra and potency depend largely on the hydrophobic portion of the molecules.

Nematocidal principles in 'oakmoss absolute' and nematocidal activity of 2,4-dihydroxybenzoates

Nematocidal principles obtained from oakmoss absolute were identified as methyl 2,4-dihydroxy-3,6-dimethylbenzoate (2), ethyl 3-formyl-2,4-dihydroxy-6-methylbenzoate (4), and ethyl 5-chloro-3-formyl-2,4-dihydroxy-6-methylbenzoate (7). In relation to their structures, the nematocidal activity of 2,4-dihydroxybenzoates of methyl to tetradecyl was tested and the strongest activity was found in the octyl ester (minimal lethal concentration=13 μM).