37629-66-6

Upstream product

• 120-57-0 piperonal 
• 140-29-4 phenylacetonitrile 
• 495-76-1 piperonol 

Downstream Products

• 1071719-18-0 3-(benzo[d][1,3]dioxol-5-yl)-2-phenylpropanenitrile 
• 682325-90-2 3-benzo[1,3]dioxol-5-yl-2-phenyl-propylamine 
• 1619942-72-1 4-(benzo[d][1,3]dioxol-5-yl)-5-phenyl-2H-1,2,3-triazole 

Relevant academic research and scientific papers

Atmosphere-Controlled Chemoselectivity: Rhodium-Catalyzed Alkylation and Olefination of Alkylnitriles with Alcohols

The chemoselective alkylation and olefination of alkylnitriles with alcohols have been developed by simply controlling the reaction atmosphere. A binuclear rhodium complex catalyzes the alkylation reaction under argon through a hydrogen-borrowing pathway and the olefination reaction under oxygen through aerobic dehydrogenation. Broad substrate scope is demonstrated, permitting the synthesis of some important organic building blocks. Mechanistic studies suggest that the alkylation product may be formed through conjugate reduction of an alkene intermediate by a rhodium hydride, whereas the formation of olefin product may be due to the oxidation of the rhodium hydride complex with molecular oxygen.

Synthesis and biological evaluation of novel 4,5-disubstituted 2H-1,2,3-triazoles as cis-constrained analogues of combretastatin A-4

A series of combretastatin A-4 (CA-4) analogues have been prepared from (Z)-substituted diarylacrylonitriles (1a-1p) obtained in a two-step synthesis from appropriate arylaldehydes and acrylonitriles. The resulting 4,5-disubstituted 2H-1,2,3-triazoles wer