3765-86-4

Usage

Type of compound

Halogenated benzimidazole derivative

Structure

Benzene ring fused to an imidazole ring with a trifluoromethyl group and an iodine atom attached at specific positions

Potential applications

Pharmaceutical and agrochemical industries as a building block for the synthesis of bioactive molecules and agrochemicals

Possible use as a fungicide or insecticide

Ability to disrupt essential biological processes in various organisms

Current status

Uses and applications are still being explored, and further research is necessary to understand its potential benefits and risks.

InChI:InChI=1/C8H4F3IN2/c9-8(10,11)7-13-5-2-1-4(12)3-6(5)14-7/h1-3H,(H,13,14)

Upstream product

• 20691-72-9 4-iodo-2-nitroaniline 

Relevant academic research and scientific papers

Exploring the Strength of the H-Bond in Synthetic Models for Heme Proteins: The Importance of the N?H Acidity of the Distal Base

The distal hydrogen bond (H-bond) in dioxygen-binding proteins is crucial for the discrimination of O2with respect to CO or NO. We report the preparation and characterization of a series of ZnIIporphyrins, with one of three meso-phenyl rings bearing both an alkyl-tethered proximal imidazole ligand and a heterocyclic distal H-bond donor connected by a rigid acetylene spacer. Previously, we had validated the corresponding CoIIcomplexes as synthetic model systems for dioxygen-binding heme proteins and demonstrated the structural requirements for proper distal H-bonding to CoII-bound dioxygen. Here, we systematically vary the H-bond donor ability of the distal heterocycles, as predicted based on pKavalues. The H-bond in the dioxygen adducts of the CoIIporphyrins was directly measured by Q-band Davies-ENDOR spectroscopy. It was shown that the strength of the hyperfine coupling between the dioxygen radical and the distal H-atom increases with enhanced acidity of the H-bond donor.