376584-05-3Relevant articles and documents
Benzodiazepine derivatives as inhibitors of gamma secretase
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, (2008/06/13)
Compounds of formula (I) are disclosed. The compounds inhibit the action of gamma secretase, and hence find use in the treatment and prevention of Alzheimer's disease.
Benzodiazepine derivatives as app modulators
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, (2008/06/13)
A novel class of 1,4- and 1,5-benzodiazepines of formula (I) is disclosed. The compounds modulate the processing of amyloid precursor protein by γ-secretase, and hence find use in the treatment or prevention of conditions associated with the deposition of β-amyloid, such as Alzheimer's disease.
New synthesis of 1,3-dihydro-1,4-benzodiazepin-2(2H)-ones and 3-amino-1,3-dihydro-1,4-benzodiazepin-2(2H)-ones: Pd-catalyzed cross-coupling of imidoyl chlorides with organoboronic acids
Nadin, Alan,Sanchez Lopez, Jose M.,Owens, Andrew P.,Howells, Dean M.,Talbot, Adam C.,Harrison, Timothy
, p. 2844 - 2852 (2007/10/03)
A new approach to the synthesis of 1,4-benzodiazepines and 3-amino-1,4-benzodiazepines, which employs the Pd-catalyzed cross-coupling reaction of an imidoyl chloride with an organometallic reagent as the key step, is described. A five-step synthesis of a
