376609-66-4

Basic information

• Product Name: 2-Methoxy-4-(1H-tetrazol-5-yl)phenol
• Synonyms: 2-Methoxy-4-(1H-tetrazol-5-yl)phenol
• CAS NO: 376609-66-4
• Molecular Formula: C₈H₈N₄O₂
• Molecular Weight: 192.17472
• Mol File: 376609-66-4.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Methoxy-4-(1H-tetrazol-5-yl)phenol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Methoxy-4-(1H-tetrazol-5-yl)phenol(376609-66-4)
• EPA Substance Registry System: 2-Methoxy-4-(1H-tetrazol-5-yl)phenol(376609-66-4)

Safety Data

• Hazardous Substances Data: 376609-66-4(Hazardous Substances Data)

Usage

Uses

2-Methoxy-4-(1H-tetrazol-5-yl)phenol is a useful reactant for the preparation TRPA1 ligands.

Upstream product

• 121-33-5 vanillin 

Relevant articles and documents

Magnetic nitrogen-doped carbon derived from silk cocoon biomass: a promising and sustainable support for copper

In this study, a magnetic nitrogen-doped carbon-based copper (MNC-Cu) catalyst was fabricated so that natural silk cocoons undergo thermal processes and then activate by combining with Fe3O4 MNPs as a suitable substrate for placement copper metal. The efficiency of the generated catalyst in the synthesis of 5-substituted 1H-tetrazole derivatives was evaluated by the [3 + 2] cycloaddition reaction of aromatic aldehydes, azide ions, and hydroxylamines. FT-IR, FE-SEM, EDS, TEM, XRD, TGA, and VSM techniques have been adopted to identify and validate this heterogeneous catalyst. The observation from EDS, elemental mapping, XRD, and FT-IR analysis confirms the immobilization of Cu metals on the MNC surface and uniform distribution of species and then no aggregation occurs during functionalization. VSM results show the magnetic feature of fabricated catalyst, and based on the leaching test, the amount of catalyst leaching was negligible. Moreover, this reaction is a one-pot multicomponent reaction (MCRs) or more precisely a one-pot, three-component reaction, which is one of the advantages of this work. The fabricated catalyst shows high efficiency, good stability, and considerable reactivity in synthesizing 5-substituted 1H-tetrazole derivatives. So it can be seen that the fabricated magnetic catalyst is a useful and practical catalyst for synthesizing [3 + 2] cycloaddition reactions. Reusability and recyclability for five sequential runs without notable increase and reduction in activity are other advantages. In addition, the magnetic properties of this heterogeneous catalyst led to easy and quickly recovered and striking copper leaching. Graphical abstract: [Figure not available: see fulltext.]

One pot three-component synthesis of 5-substituted 1H-tetrazole from aldehyde

A versatile, robust and efficient strategy for the synthesis of vast range of highly functionalized 5-substituted 1H-tetrazole derivatives by using one pot three-component synthesis from various aldehydes, hydroxylamine hydrochloride and sodium azide in p