37664-01-0

Upstream product

• 99-73-0 para-bromophenacyl bromide 
• 37664-32-7 2-(1H-1,2,4-triazol-3-ylthio)-1-(4-bromophenyl) ethanone 

Downstream Products

• 1423120-83-5 6-(4-bromophenyl)-5-(4-(trifluoromethyl)phenyl)thiazolo[3,2-b]-1,2,4-triazole 
• 1423120-89-1 6-(4-bromophenyl)-5-(3-fluorophenyl)thiazolo[3,2-b]-1,2,4-triazole 
• 1423120-90-4 6-(4-bromophenyl)-5-(naphthalen-1-yl)thiazolo[3,2-b]-1,2,4-triazole 
• 1580471-62-0 C₁₆H₁₆BrF₃N₄OS₂ 

Relevant academic research and scientific papers

Synthesis of 6-Aryl-4H-imidazo[1,2-b][1,2,4]triazoles and 6-Aryl-thiazolo[3,2-b][1,2,4]triazoles

The cyclization of the derivatives of 3-aminotriazole, 2-(5-substituted 4H-1,2,4-triazol-3-ylamino)-1-arylethanones and 2-(4H-1,2,4-triazol-3-ylthio)-1-arylethanones to yield 6-aryl-4H-imidazo[1,2-b][1,2,4]triazoles and 6-aryl-thiazolo[3,2-b][1,2,4]triazoles has been described.

Cu-catalyzed direct C-H bond functionalization: A regioselective protocol to 5-aryl thiazolo[3,2-b]-1,2,4-triazoles

An efficient, regioselective C-5 arylation of thiazolo[3,2-b]-1,2,4- triazoles catalyzed by a simple copper catalyst was developed. This arylation proceeded smoothly and tolerated a variety of functional groups (44 examples). A wide range of functionalized thiazolo[3,2-b]-1,2,4-triazole derivatives were obtained in high yields (up to 99% yield). Possible catalytic cycles of the arylation were also discussed.