37673-10-2 Usage
Nitrile derivative
The compound contains a nitrile functional group (CN), which is a cyano group attached to an alkyl or aryl group.
Benzodioxole ring
The compound has a benzodioxole ring, which is a six-membered aromatic ring with two oxygen atoms attached to it.
Morpholine group
The compound has a morpholine group, which is a five-membered ring with four methylene groups and one nitrogen atom.
Acetonitrile functional group
The compound has an acetonitrile group (CH3CN), which is a cyano group attached to a methyl group.
Used as an intermediate
The compound is primarily used as an intermediate for the synthesis of other pharmaceuticals and organic compounds.
Potential applications in medicinal chemistry and drug development
Due to its unique structural features, the compound may have potential applications in the development of new drugs and therapies.
Solid at room temperature
The compound is a solid at room temperature, which affects its handling and storage.
Handled in a controlled laboratory environment
Due to its potential hazards and reactivity, the compound should be handled in a controlled laboratory environment with proper safety measures.
Check Digit Verification of cas no
The CAS Registry Mumber 37673-10-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,7,6,7 and 3 respectively; the second part has 2 digits, 1 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 37673-10:
(7*3)+(6*7)+(5*6)+(4*7)+(3*3)+(2*1)+(1*0)=132
132 % 10 = 2
So 37673-10-2 is a valid CAS Registry Number.
37673-10-2Relevant articles and documents
Derivatives of 1,3-benzdioxoles, 53. Preparation of N-alkyl-2-aryl-pyrrolidines
Dallacker,Jouck
, p. 1598 - 1606 (1984)
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Steric Inhibition of Synergistic Radical Stabilizing Effects
Bordwell, F. G.,Bausch, Mark J.,Cheng, Jin-Pei,Cripe, Thomas H.,Lynch, Tsuei-Yun,Mueller, Mark E.
, p. 58 - 63 (2007/10/02)
Equilibrium acidities in Me2SO for 14 α-N-morpholinyl-, 6 α-N-piperidinyl-, and 7 α-cyclohexylarylacetonitriles and the oxidation potentials of their conjugate bases have been determined.The increased pKHA values by about 2 units observed in these systems, relative to the corresponding arylacetonitriles, is ascribed to the presence of increased steric constraints in the anions.Hammett plots revealed larger ρ values than for arylacetonitriles (6-7 versus 5.5), pointing to an increased negative charge density on the benzylic carbon atoms in the anions.A plot of anion oxidation potentials, Eox(A-), versus pKHA for the α-N-morpholinylarylacetonitriles was linear with a slope near unity, showing that remote substituents for the most part have very little effect on radical stabilities.A 5 and 6 kcal/mol lowering of the BDE of the acidic C-H bond caused by replacing the cyclohexyl group in α-cyclohexylphenylacetonitrile by α-N-morpholinyl or N-piperidinyl groups, respectively, is attributed to the strong donor properties of these amino functions.The effects are only about one-third as large, however, as similar effects in R2NCH2COPh, where the steric effect of Ph is absent and a synergistic effect is believed to be operative.