37682-72-7 Usage
Uses
Used in Research Applications:
Antipain, dihydrochloride is used as a research tool to evaluate the role of proteases in cell transformations. It helps in identifying new proteases and understanding their functions in various biological processes.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, Antipain, dihydrochloride is used as a protease inhibitor for the development of drugs targeting proteases involved in various diseases and conditions.
Used in Biochemical Analysis:
Antipain, dihydrochloride is used in biochemical analysis to study the activity and specificity of different proteases, as well as their interactions with other molecules.
Used in Drug Discovery:
Antipain, dihydrochloride is used in drug discovery to identify potential therapeutic agents that can modulate the activity of proteases, which may have implications in the treatment of various diseases.
Used in Enzyme Assays:
Antipain, dihydrochloride is used in enzyme assays to determine the activity of proteases and to establish the optimal conditions for their function.
Used in Cell Culture Studies:
Antipain, dihydrochloride is used in cell culture studies to investigate the effects of protease inhibition on cell growth, differentiation, and transformation.
Used in Pathology Research:
Antipain, dihydrochloride is used in pathology research to study the role of proteases in the development and progression of diseases, such as cancer and inflammatory conditions.
Used in Molecular Biology:
Antipain, dihydrochloride is used in molecular biology to investigate the regulation of protease activity at the molecular level and its impact on cellular processes.
Used in Toxicology Studies:
Antipain, dihydrochloride is used in toxicology studies to assess the potential toxic effects of protease inhibitors and their impact on cellular and tissue function.
Used in Diagnostic Applications:
Antipain, dihydrochloride is used in diagnostic applications to develop assays for the detection and quantification of protease activity in biological samples, which may aid in the diagnosis of various diseases and conditions.
Biochem/physiol Actions
Reversible inhibitor of serine/cysteine proteases and some trypsin-like serine proteases. Its action resembles leupeptin; however, its plasmin inhibition is less and its cathepsin A inhibition is more than that observed with leupeptin. Chronic administration of antipain can reduce the frequency of chemically induced transformation in BALB/c-/3T3 cells.
References
1) Umezawa?et al.?(1976),?Structures and activities of protease inhibitors of microbial origin; Method Enzymol.,?45?678
2) Gotoh?et al.?(2001),?Proteolytic activity and recombinant protein production in virus-infected Sf-9 insect cell cultures supplemented with carboxyl and cysteine protease inhibitors; J. Biosci. Bioeng.,?92?248
3) Hockensmith?et al. (2016), Identification and characterization of a chymotrypsin-like serine protease from periodontal pathogen, Tannerella forsythia; Microb. Pathog.,?100?37
4) Mat Amin?et al. (2004),?Proteinases in Naegleria Fowleri (strain NF3), a pathogenic amoeba: a preliminary study.; Trop. Biomed.,?21?57
5) Moriyyasu & Inoue (2008),?Use of protease inhibitor for detecting autophagy in plants; Methods Enzymol.,?451?557
Check Digit Verification of cas no
The CAS Registry Mumber 37682-72-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,7,6,8 and 2 respectively; the second part has 2 digits, 7 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 37682-72:
(7*3)+(6*7)+(5*6)+(4*8)+(3*2)+(2*7)+(1*2)=147
147 % 10 = 7
So 37682-72-7 is a valid CAS Registry Number.
InChI:InChI=1/C27H44N10O6.2ClH/c1-16(2)21(34-18(15-38)10-6-12-32-25(28)29)23(40)37-22(39)19(11-7-13-33-26(30)31)35-27(43)36-20(24(41)42)14-17-8-4-3-5-9-17;;/h3-5,8-9,15-16,18-21,34H,6-7,10-14H2,1-2H3,(H,41,42)(H4,28,29,32)(H4,30,31,33)(H2,35,36,43)(H,37,39,40);2*1H/t18?,19-,20?,21-;;/m0../s1
