37696-36-9Relevant academic research and scientific papers
Simple and efficient preparation of (R)- and (S)-enantiomers of α-carbon deuterium-labelled α-amino acids
Mitulovi, Goran,Laemmerhofer, Michael,Maier,Lindner, Wolfgang
, p. 449 - 461 (2007/10/03)
A procedure for the synthesis of (R)- and (S)-enantiomers of α-carbon deuterium-labelled α-amino acids, exemplified for (R)- and (S)-[2-2H1]-Leu is described. Starting from the respective (S)- or (R)-enantiomer or from the racemic mixture of an α-amino acid the selective proton exchange at the α-carbon is carried out by racemization via a Schiff base in monodeuterated acetic acid as solvent which serves as deuterium source. After N-protection the racemic mixture is liquid chromatographically separated into the individual (R)- and (S)-enantiomers on preparative scale employing a chiral anion exchanger based on carbamoylated quinine as chiral selector. After deprotection the enantiomerically pure products can be obtained in good yields.
Circular dichroism, ultraviolet, and proton nuclear magnetic resonance spectroscopic studies of the chiral recognition mechanism of β-cyclodextrin
Purdy, William C.
, p. 1405 - 1412 (2007/10/02)
The chiral recognition mechanism of β-cyclodextrin was studied by UV-visible, circular dichroism, and proton nuclear magnetic resonance spectroscopic methods. The D and L enantiomers of DNP-valine, DNP-leucine, and DNP-methionine were used as model solute
