37707-23-6 Usage
General Description
N-Monodesmethyl promethazine is a metabolite of the drug promethazine, which is commonly used as an antihistamine and antiemetic. It is formed through the process of demethylation, where one of the methyl groups on promethazine is removed. N-Monodesmethyl promethazine retains some of the pharmacological activities of promethazine, including antihistaminic, sedative, and antiemetic effects, although it is generally weaker in potency. This metabolite is primarily excreted in the urine, and its levels in the body may be influenced by factors such as genetic variability in drug metabolism or concomitant use of other medications. N-Monodesmethyl promethazine is important in understanding the pharmacokinetics and pharmacodynamics of promethazine, as well as in monitoring its use and potential adverse effects in patients.
Check Digit Verification of cas no
The CAS Registry Mumber 37707-23-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,7,7,0 and 7 respectively; the second part has 2 digits, 2 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 37707-23:
(7*3)+(6*7)+(5*7)+(4*0)+(3*7)+(2*2)+(1*3)=126
126 % 10 = 6
So 37707-23-6 is a valid CAS Registry Number.
InChI:InChI=1/C16H18N2S/c1-12(17-2)11-18-13-7-3-5-9-15(13)19-16-10-6-4-8-14(16)18/h3-10,12,17H,11H2,1-2H3
37707-23-6Relevant articles and documents
Design, synthesis, and validation of a novel [11c]promethazine pet probe for imaging abeta using autoradiography
Behof, William J.,Boules, Mariam I.,Haynes, Justin R.,Koktysh, Dmitry,Pham, Wellington,Rosenberg, Adam J.,Tantawy, Mohammed N.,Whitmore, Clayton A.
, (2021/05/28)
Promethazine, an antihistamine drug used in the clinical treatment of nausea, has been demonstrated the ability to bind Abeta in a transgenic mouse model of Alzheimer’s disease. However, so far, all of the studies were performed in vitro using extracted tissues. In this work, we report the design and synthesis of a novel [11C]promethazine PET radioligand for future in vivo studies. The [11C]promethazine was isolated by RP-HPLC with radiochemical purity >95% and molar activity of 48 TBq/mmol. The specificity of the probe was demonstrated using human hippocampal tissues via autoradiography.
Coupling body-benzonorbornene oligomer- (by machine translation)
-
Paragraph 0190; 0191, (2016/10/07)
The invention relates to (among other things) oligomer-phenothiazine conjugates and related compounds. A conjugate of the invention, when administered by any of a number of administration routes, exhibits advantages over un-conjugated phenothiazine compounds.
