37708-30-8Relevant academic research and scientific papers
Hypocholesterolemic unsymmetrical dithiol ketals
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, (2008/06/13)
Disclosed herein are novel unsymmetrical dithiol ketals which are useful in the treatment or prevention of hypercholesterolemia, hyperlipoproteinemia, and atherosclerosis.
Quantitative structure-activity relationships in dihydropteroate synthase inhibition by multisubstituted sulfones. Design and synthesis of some new derivatives with improved potency
De Benedetti,Iarossi,Folli,Frassineti,Menziani,Cennamo
, p. 2396 - 2399 (2007/10/02)
On the bases of the linear correlation existing for a training set of homomultisubstituted 4-aminodiphenyl sulfones between the computed (INDO) electronic net charges of the SO2 group and the enzymic inhibition data on dihydropteroate synthase from Escherichia coli, seven new heteromultisubstituted derivatives were designed, synthesized, and tested for their inhibition potencies. These compounds were found to be from 5-11 times more effective than 4,4'-diaminodiphenyl sulfone. The implications of the results in the drug design and in the model for the enzyme-inhibitors interaction are discussed.
2,6-Dialkyl-4-hydroxysulfenyl chlorides
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, (2008/06/13)
2,6-dialkyl-4-hydroxysulfenyl chlorides are prepared by reacting sulfur chloride with an equimolar amount of a 3,5-dialkyl phenol. The sulfenyl chlorides are novel compounds useful as intermediates in the preparation of other compounds. For example, they
