377091-17-3Relevant academic research and scientific papers
Practical asymmetric synthesis of a selective endothelin A receptor (ETA) antagonist
Song, Zhiguo J.,Zhao, Matthew,Frey, Lisa,Li, Jing,Tan, Lushi,Chen, Cheng Y.,Tschaen, David M.,Tillyer, Richard,Grabowski, Edward J. J.,Volante, Ralph,Reider, Paul J.,Kato, Yoshiaki,Okada, Shigemitsu,Nemoto, Takayuki,Sato, Hiroki,Akao, Atsushi,Mase, Toshiaki
, p. 3357 - 3360 (2001)
Equation presented A practical, chromotography-free asymmetric synthesis was developed for the large scale preparation of an endothelin receptor antagonist 2. This synthesis includes a new efficient process for the preparation of 6-bromo-2,3-dihydrobenzof
SPIRO COMPOUNDS AS GLYCOSIDASE INHIBITORS
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Page/Page column 106, (2020/03/15)
Compounds of formula (I) wherein A, R, L, Z, Q1, Q2 and n have the meaning according to the claims can be employed, inter alia, for the treatment of tauopathies and Alzheimer's disease.
TETRAHYDRO-BENZOAZEPINE GLYCOSIDASE INHIBITORS
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Page/Page column 129, (2020/03/15)
Compounds of formula (I') wherein A, R1, R2, T1, T2, T3, T4, L, W, Z, R''', m and n have the meaning according to the claims can be employed, inter alia, for the treatment of tauopathies and Alzheimer's disease.
FUSED GLYCOSIDASE INHIBITORS
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Page/Page column 117, (2020/09/08)
Compounds of formula (I), wherein A, Z, E, R1, R2, m and n have the meaning according to the claims can be employed, inter alia, for the treatment of tauopathies and Alzheimer's disease.
ANNULATED GLYCOSIDASE INHIBITORS
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Page/Page column 89; 90, (2019/03/12)
Compounds of formula (I) wherein A, R, W1, W2, W3, W4, W5, W6, L, Q, Rx and u have the meaning according to the claims can be employed, inter alia, for the treatment of tauopathies and Alzheimer's disease.
LINEAR GLYCOSIDASE INHIBITORS
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Page/Page column 60, (2019/03/14)
Compounds of formula (I) wherein A, R, W, Q, L, n and m have the meaning according to the claims can be employed, inter alia, for the treatment of tauopathies and Alzheimer's disease.
PROCESS FOR THE SEPARATION OF ENANTIOMERS OF PIPERAZINE DERIVATIVES
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Page/Page column 32-34, (2017/09/21)
The invention relates to a process for preparing either enantiomer of a compound of formula (I), wherein X, Y and n have the meaning given in claim 1, with high enantiomeric excess (e.e.), by chiral resolution in the presence of a non-racemic, chiral acid.
GLYCOSIDASE INHIBITORS
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Page/Page column 97; 98, (2017/09/15)
Compounds of formula (I) wherein A, R, W, Q, n and m have the meaning according to the claims can be employed, inter alia, for the treatment of tauopathies and Alzheimer's disease.
GLYCOSIDASE INHIBITORS
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Page/Page column 82-83, (2017/09/15)
Compounds of formula (I) wherein A, R, W, Q, n and m have the meaning according to the claims can be employed, inter alia, for the treatment of tauopathies and Alzheimer's disease.
Heterocyclic compound
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Paragraph 1106, (2016/10/08)
The present invention relates to compound (I) or a salt thereof which has a ROR γ t inhibitory action. wherein each symbol is as defined in the specification.
