377092-98-3

Upstream product

• 638-10-8 ethyl 3-methylbut-2-enoate 
• 100-53-8 phenylmethanethiol 
• 106-38-7 para-bromotoluene 
• 17903-42-3 (4-(bromomethyl)phenyl)trimethylsilane 
• 57337-85-6 trimethyl(4-mercaptomethylphenyl)silane 
• 3728-43-6 p-(trimethylsilyl)toluene 
• 497181-05-2 3-methyl-3-(4-trimethylsilanyl-benzylsulfanyl)-butyric acid ethyl ester 

Downstream Products

• 561329-03-1 trans-4,4-dimethyl-2-(m-trifluoromethylstyryl)-1,3-oxathiane 
• 561329-02-0 trans-2-(p-bromostyryl)-4,4-dimethyl-1,3-oxathiane 
• 561329-04-2 trans-4,4-dimethyl-2-(3-phenyl-1-propenyl)-1,3-oxathiane 
• 561329-01-9 trans-2-(p-methoxystyryl)-4,4-dimethyl-1,3-oxathiane 
• 444880-01-7 (E)-2-(2-phenyl-ethenyl)-4,4-dimethyl-1,3-oxathiane 
• 34300-94-2 3-Methyl-3-sulfanylbutan-1-ol 
• 74252-98-5 3-methyl-3-thiobenzylbutan-1-ol 

Relevant academic research and scientific papers

Development of Odorless Thiols and Sulfides and Their Applications to Organic Synthesis

Development of new odorless thiols (dodecanethiol, 4-n- heptylphenylmethanethiol, 4-trimethylsilylphenylmethanethiol, 4-trimethylsilylbenzenethiol) and an odorless sulfide (1-methylsulfanyldodecane) and their applications to dealkylation, Michael addition, Swern oxidation, and Corey-Kim oxidation are described.

A novel tandem [4++2] cycloaddition-elimination reaction: 2-alkenyl-4,4-dimethyl-1,3-oxathianes as synthetic equivalents for α,β-unsaturated thioaldehydes

The first tandem cationic [4++2] polar cycloaddition-elimination reaction of 1-thia-1,3-butadienyl cations B with olefins to afford directly 3,4-dihydro-2H-thiopyrans D is described. The cations B were easily accessible by treatment of monothioacetals A, particularly the 2-alkenyl-4,4-dimethyl-1,3-oxathianes 1, with a hard Lewis acid. In this novel reaction, 2-alkenyl-4,4-dimethyl-1,3-oxathianes were utilized as synthetic equivalents for highly reactive α,β-unsaturated thioaldehydes. The effect of geminal dimethyl substituents on the oxathianes 1 and the mechanistic aspect of the reaction are considered. The reaction's asymmetric version was also investigated using a chiral oxathiane 4 derived from (-)-(1R,2R,5R)-2-(1-mercapto-1-methylethyl)-5-methylcyclohexanol. Although the enantioselectivities were moderate, the whole process can be done under odorless conditions.

Synthetic equivalents of benzenethiol and benzyl mercaptan having faint smell: Odor reducing effect of trialkylsilyl group

Syntheses and odor tests of the trialkylsilylated benzyl mercaptans and benzenethiols have revealed that the trimethylsilyl substituent on the benzene ring has a remarkable effect in reducing the foul smell of the parent benzyl mercaptan and benzenethiol.