3771-31-1

Usage

Uses

Used in Laboratory Applications:
Methyl Orange is used as a pH indicator in titrations for determining the acidity or alkalinity of a solution. Its color change, from yellow to orange, assists in identifying the pH levels accurately.
Used in Chemical Education:
In educational settings, Methyl Orange is utilized for teaching purposes, particularly in chemistry classes, to demonstrate the concept of pH and the use of indicators in acid-base titrations.
Used in Research:
Methyl Orange is also employed in various research applications, where its color-changing properties can be instrumental in studying pH-dependent reactions and processes.
Used in Analytical Chemistry:
In the field of analytical chemistry, Methyl Orange serves as a valuable tool for qualitative and quantitative analysis, helping to determine the endpoint of titrations and assess the concentration of acids or bases in a solution.

InChI:InChI=1/C16H16N4OS/c1-20(2)12-6-4-11(5-7-12)18-19-16-17-14-9-8-13(21-3)10-15(14)22-16/h4-10H,1-3H3/b19-18+

Upstream product

• 121-69-7 N,N-dimethyl-aniline 
• 1747-60-0 6-methoxybenzothiazol-2-ylamine 

Downstream Products

• 1101125-78-3 C₁₉H₂₂BrN₄OS⁽¹⁺⁾ 
• 38901-83-6 2-(4-dimethylamino-phenylazo)-6-methoxy-3-methyl-benzothiazolium 

Relevant academic research and scientific papers

Discovery of Small Molecules that Induce the Degradation of Huntingtin

Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder caused by the aggregation of mutant huntingtin (mHtt), and removal of toxic mHtt is expected to be an effective therapeutic approach. We designed two small hybrid molecules (1 and 2) by linking a ligand for ubiquitin ligase (cellular inhibitor of apoptosis protein 1; cIAP1) with probes for mHtt aggregates, anticipating that these compounds would recruit cIAP1 to mHtt and induce selective degradation by the ubiquitin-proteasome system. The synthesized compounds reduced mHtt levels in HD patient fibroblasts and appear to be promising candidates for the development of a treatment for HD.

SULFIDE DYES

Formula (I) wherein R1 and R2 each independently from each other are a residue of an organic dye; Y1 and Y2 each independently from each other are unsubstituted or substituted, straightchain or branched, interrupted or uninterrupted -C1-C10alkylene-; -C5-C10cycloalkylene-; C5-C10arylene; or-C5-C10arylene-(C1-C10alkylene)-; Z1 and Z2 independently from each other are Formula (II) are each independently from each other hydrogen; or unsubstituted or substituted, straight-chain or branched, monocyclic or polycyclic, interrupted or uninterrupted C1-C14alkyl; C2-C14alkenyl; C6-C10aryl; C6-C10aryl-C1-C10alkyl; or C5-C10alkyl(C5-C10aryl); r, q and n independently from each other are 0 or 1, if n is 0, Z3 is hydrogen; and if n is 1, Z3 is -S-; with the proviso that the method does not comprise treating the fiber with an enzyme of the type of a protein disulfidisomerase (EC 5.3.4.1). Further, the present invention relates to novel disulfid compounds, compositions thereof, especially comprising other dyes, and to processes for their preparation.