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(14R)-Grayanotoxane-2α,3β,5,6β,10,14,16-heptol is a naturally occurring toxic diterpenoid compound found in certain plants, particularly in members of the Rhododendron genus. It possesses a complex and potentially lethal structure with potent neurotoxic effects, primarily exerted by binding to and altering the function of voltage-gated sodium channels in nerve cells.
Used in Pharmaceutical Industry:
(14R)-Grayanotoxane-2α,3β,5,6β,10,14,16-heptol is used as a research compound for studying its neurotoxic properties and potential applications in drug development. Its interaction with voltage-gated sodium channels makes it a valuable tool for understanding the mechanisms of action of various neurotoxins and developing countermeasures or treatments for poisoning.
Used in Toxicological Research:
(14R)-Grayanotoxane-2α,3β,5,6β,10,14,16-heptol is used as a model toxic compound in toxicological research to investigate the effects of plant-derived neurotoxins on human and animal health. This research can contribute to the development of antidotes, risk assessment, and guidelines for safe handling and consumption of plants containing this chemical.
Used in Environmental and Wildlife Protection:
(14R)-Grayanotoxane-2α,3β,5,6β,10,14,16-heptol is used as a reference toxicant in environmental and wildlife protection efforts to raise awareness about the risks posed by plants containing this chemical. This can help in the development of strategies to protect both humans and animals from accidental ingestion or exposure to toxic plants.

37720-87-9

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37720-87-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 37720-87-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,7,7,2 and 0 respectively; the second part has 2 digits, 8 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 37720-87:
(7*3)+(6*7)+(5*7)+(4*2)+(3*0)+(2*8)+(1*7)=129
129 % 10 = 9
So 37720-87-9 is a valid CAS Registry Number.
InChI:InChI=1/C20H34O7/c1-16(2)15(24)12(22)13-18(4,26)10-6-5-9-14(23)19(10,8-17(9,3)25)7-11(21)20(13,16)27/h9-15,21-27H,5-8H2,1-4H3

37720-87-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name Rhodojaponin VI

1.2 Other means of identification

Product number -
Other names grayanotoxane-2,3,5,6,10,14,16-heptol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:37720-87-9 SDS

37720-87-9Downstream Products

37720-87-9Relevant academic research and scientific papers

Iridoid glycosides and grayanane diterpenoids from the roots of Craibiodendron henryi

Huang, Xiang-Zhong,Wang, Ying-Hong,Yu, Shi-Shan,Fu, Guang-Miao,Hu, You-Cai,Liu, Yue,Fan, Li-Hua

, p. 1646 - 1650 (2005)

Four new iridoid glycosides, 10-O-trans-p-coumaroylscandoside (1), 10-O-cis-p-coumaroylscandoside (2), 10-O-trans-p-coumaroyldesacetyl asperulosidic acid (3), and 10-O-cis-p-coumaroyldesacetyl asperulosidic acid (4), and two new grayanane diterpenoids, 14β-O-(2S,3S-nilyl)-2α, 3β,5β,6β,16α-pentahydroxygrayanane (5) and 14β-O-(2S,3S-nilyl)-2α,3β,5β,6β,16α- pentahydroxygrayan-10(20)-ene (6), have been isolated from Craibiodendron henryi. The structures of these compounds were determined by chemical and spectroscopic methods including 1H-1H COSY, HMQC, HMBC, and NOESY experiments. Antioxidant activities and vasodilator effects of these compounds were assessed.

Accumulation of Highly Toxic Ericaceous Diterpenoids by the Geometrid Moth, Arichanna gaschkevitchii

Nishida, Ritsuo,Fukami, Hiroshi,Iriye, Ryozo,Kumazawa, Zenzaburo

, p. 2347 - 2352 (2007/10/02)

Adults of geometrid moth, Arichanna gaschkevitchii, were found to store grayanoid diterpenes originating from the larval host plant, Pieris japonica (Ericaceae), in the body tissue.The compounds were characterized as asebotoxins I and IV, grayanotoxin III, rhodojaponin III, kalmitoxin I and two new analogs, arichannatoxin I and II.The content of the total grayanoid analogs in the body tissue was as high as 300μg/moth.The most predominant component, asebotoxin I (200μg/moth), strongly deterred feeding of house lizards, which suggests a defensive role against predatory animals.

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