37748-19-9

Basic information

• Product Name: Phosphonium, triphenyl(4-phenylbutyl)-, bromide
• CAS NO: 37748-19-9
• Molecular Formula: C28H28P.Br
• Molecular Weight: 475.408
• Mol File: 37748-19-9.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: Phosphonium, triphenyl(4-phenylbutyl)-, bromide(CAS DataBase Reference)
• NIST Chemistry Reference: Phosphonium, triphenyl(4-phenylbutyl)-, bromide(37748-19-9)
• EPA Substance Registry System: Phosphonium, triphenyl(4-phenylbutyl)-, bromide(37748-19-9)

Safety Data

• Hazardous Substances Data: 37748-19-9(Hazardous Substances Data)

Upstream product

• 13633-25-5 1-Bromo-4-phenylbutane 
• 603-35-0 triphenylphosphine 

Downstream Products

• 175234-01-2 2-methyl-9-phenyl-cis-1,5-nonadiene 
• 54928-28-8 (5-methylhex-4-en-1-yl)benzene 
• 1217298-12-8 C₂₁H₃₁NO₃ 
• 1217298-11-7 C₂₁H₃₁NO₃ 
• 301219-69-2 (R)-Cyclohexyl-{(3S,4S)-3-[4-(2-ethyl-4-phenethyl-2H-pyrazol-3-yl)-piperidin-1-ylmethyl]-4-phenyl-pyrrolidin-1-yl}-acetic acid benzyl ester 

Relevant articles and documents

Antagonists of human CCR5 receptor containing 4-(pyrazolyl)piperidine side chains. Part 1: Discovery and SAR study of 4-pyrazolylpiperidine side chains

Replacement of the flexible connecting chains between the piperidine moiety and an aromatic group in previous CCR5 antagonists with heterocycles, such as pyrazole and isoxazole, provided potent CCR5 antagonists with excellent anti-HIV-1 activity in vitro. SAR studies revealed optimal placement of an unsubstituted nitrogen atom in the heterocycle to be meta to the bond connected to the 4-position of piperidine. Truncation of a benzyl group to a phenyl group afforded compounds with dramatically improved oral bioavailability, albeit with reduced activity.

Syntheses and biological activities of KRN7000 analogues having aromatic residues in the acyl and backbone chains with varying stereochemistry

KRN7000 is an important ligand identified for CD1d protein of APC, and KRN7000/CD1d complex can stimulate NKT cells to release a broad range of bioactive cytokines. In an effort to understand the structure-activity relationships, we have carried out synth

Alkenoic acid derivatives

An alkenoic acid derivative of the formula STR1 in which X and Y are identical or different and represent sulfur, sulfoxide, sulfone, an alkylene chain, --SCH2 --, or oxygen or a direct bond, W represents --CH=CH-- or --CH2 --CH2 --, o represents a number 1 to 5, A and B are identical or different and represent carboxyl, carboxymethylene, tetrazolyl or tetrazolylmethylene, or --CO2 R9 or --CH2 CO2 R9 or --CONR10 R11 or nitrile n represents a number 1 to 10, m represents a number 0 to 7, T and Z are identical or different and represent oxygen or a direct bond and R2, R3, R8 are identical or different and represent hydrogen, alkyl, alkoxy, halogen, trifluoromethyl, trifluoromethoxy, cyano or nitro and R9 is lower alkyl and R10 and R11 are hydrogen, lower alkyl, alkylsulfonyl or arylsulfonyl or together are an alkylene chain to form a ring and pharmaceutically acceptable salts thereof. Such alkenoic acid derivatives are useful as leucotriene disease antagonists.