3775-71-1Relevant academic research and scientific papers
Evaluating β-amino acids as enantioselective organocatalysts of the Hajos-Parrish-Eder-Sauer-Wiechert reaction
Davies, Stephen G.,Russell, Angela J.,Sheppard, Ruth L.,Smith, Andrew D.,Thomson, James E.
, p. 3190 - 3200 (2008/03/14)
A systematic study of the effect of substitution within the β-amino acid framework indicates that both β2- and β3- amino acids catalyse the Hajos-Parrish-Eder-Sauer-Wiechert reaction with poor to reasonable levels of enantioselectivity. These results led to the evaluation of the conformationally constrained β-amino acid (1R,2S)-cispentacin, which catalyses the Hajos-Parrish-Eder-Sauer-Wiechert reaction with comparable or higher levels of enantioselectivity to l-proline. The Royal Society of Chemistry.
Synthesis and Stereochemistry of Chiral Azetidin-2-ones and Azetidine-2-thiones. I. Synthesis of Diastereomeric 2- and 3-Substituted N-(α-Methylbenzyl)-β-aminopropionic Acids
Romanova, N. N.,Tallo, T. G.,Bundel', Yu. G.
, p. 375 - 377 (2007/10/03)
Nucleophilic addition of α-methylbenzylamine to the double bond of 2- and 3-substituted acrylic acids in pyridine under reflux proceeds nonstereoselectively.
STEREOCHEMISTRY OF THE METHYLATION OF THE (11S,4S) AND (11S,4R) DIASTEREOMERS OF 4-METHYL-1-(α-METHYLBENZYL)AZETIDIN-2-ONE
Romanova, N. N.,Tallo, T. G.,Borisenko, A. A.,Bundel', Yu. G.
, p. 761 - 766 (2007/10/02)
The methylation of the lithium derivatives of the (11S,4S) and (11S,4R) diastereomers of 4-methyl-1-(α-methylbenzyl)azetidin-2-one proceeds stereospecifically with the formation of only trans-(3S,4S)- and trans-(3R,4R)-dimethyl-1-(S
ASYMMETRIC SYNTHESIS WITH CHIRAL HYDROXYLAMINES. SYNTHESIS OF OPTICALLY PURE 4-SUBSTITUTED AZETIDINONES
Baldwin, S. W.,Aube, J.
, p. 179 - 182 (2007/10/02)
The reaction between β-substituted acrylate esters and α-methylbenzyl hydroxyl amine affords diastereoisomeric 5-isoxazolidinones, convenient precursors of simple optically pure 2-azetidinones.
