37758-47-7

Basic information

• Product Name: GANGLIOSIDE GM1, AMMONIUM SALT, BOVINE
• Synonyms: Ganglioside M1;GM1;GM1 Ganglioside (Brain, Ovine-SodiuM Salt);GM1 Ganglioside (Brain, Ovine-Sodium Salt);Monosialotetrahexosylganglioside Sodium;Ganglioside GM1 (Ovine Brain);Ganglioside GM?, Ammonium Salt, Bovine Brain;Sodium Monosialotetrahexosylganglioside Injection
• CAS NO: 37758-47-7
• Molecular Formula: C73H134N4O31
• Molecular Weight: 1563.85
• EINECS: 200-081-4
• Mol File: 37758-47-7.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 1527 °C at 760 mmHg
• Flash Point: 877.3 °C
• Appearance: /lyophilized powder
• Density: 1.35 g/cm³
• Storage Temp.: −20°C
• Solubility: chloroform/methanol (9:1): 10 mg/mL, clear, colorless
• Water Solubility: soluble in chloroform/methanol (9:1): 10 mg/mL
• Merck: 14,4364
• CAS DataBase Reference: GANGLIOSIDE GM1, AMMONIUM SALT, BOVINE(CAS DataBase Reference)
• NIST Chemistry Reference: GANGLIOSIDE GM1, AMMONIUM SALT, BOVINE(37758-47-7)
• EPA Substance Registry System: GANGLIOSIDE GM1, AMMONIUM SALT, BOVINE(37758-47-7)

Safety Data

• Statements: R22;R24/25:
• Safety Statements: 22-24/25
• WGK Germany: 3
• RTECS: FK1200000
• F: 10-21
• Hazardous Substances Data: 37758-47-7(Hazardous Substances Data)

Usage

Chemical Properties

Off-white powder

Uses

Ganglioside GM1 (Ovine Brain) has been used in the preparation of small unilamellar vesicles for fluorescence studies. It has also been used in liposome preparation for circular dichroism studies with human wild type?synuclein. It may be used as a standard lipid for electrospray ionization (ESI) mass spectrometry (MS) analysis.

Definition

ChEBI: A sialotetraosylceramide consisting of a branched pentasaccharide made up from one sialyl residue, two galactose residues, one N-acetylgalactosamine residue and a glucose residue at the reducing end attached to N-stear ylsphingosine via a beta-linkage.

General Description

Ganglioside GM1 is referred as brain ganglioside. It is an acidic glycosphingolipid comprising N-acetylneuraminic acid or N-glycolylneuraminic acid residues. It is upregulated in developing brain. Ganglioside GM1 has five glycosyl units.

Biochem/physiol Actions

Ganglioside GM1 is a modulator of Ca2+ flux in plasmamembrane. It plays a key role in neuronal development and maturation and has neuroprotective functionality. GM1 ganglioside from ovine has many pharmaceutical applications and is regarded as an effective therapeutic for Huntington′s disease. Accumulation of GM1 in brain due to β-galactosidase enzyme deficiency is implicated in metabolic disorder, GM1 gangliosidosis.